Sadovnick Dessa, Criscuoli Maria, Yee Irene, Carruthers Robert, Schabas Alice, Smyth Penelope
Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada.
Mult Scler J Exp Transl Clin. 2021 Jul 15;7(3):20552173211032313. doi: 10.1177/20552173211032313. eCollection 2021 Jul-Sep.
The objective of this prospective "real world" study is to gain insight into the different "roads to conception" that women with MS take as part of the prospective Canadian Multiple Sclerosis Pregnancy Study (CANPREG-MS).
Participants are women with MS who are planning a pregnancy. Data cut-off for analyses was April 30, 2020.
We believe this is the first prospective National study of women with MS planning pregnancies.The data are for the first 44 women enrolled of whom 26 achieved pregnancy by cut-off date. Seven women used assisted reproductive technologies (ARTs); 6 stopped disease modifying therapy (DMT) against their neurologists' recommendations; 6 had an interruption(s) in trying to conceive due to MS relapses, MRI-detected inflammation, or limited "windows of opportunity" between DMT courses.
The study illustrates the roads that women take to conception, even if they are on the same therapy and have similar clinical expression of MS. Advice given by treating neurologists on washout periods show discrepancies. This paper highlights the real problem that there is no definitive, international consensus on managing these women due to the lack of "real world" data and thus the goal of CANPREG-MS is to provide such real world data.
这项前瞻性“真实世界”研究的目的是深入了解患有多发性硬化症（MS）的女性在未来加拿大多发性硬化症妊娠研究（CANPREG-MS）中所采取的不同“受孕途径”。
参与者为计划怀孕的患有MS的女性。分析的数据截止日期为2020年4月30日。
我们认为这是第一项针对计划怀孕的患有MS的女性的前瞻性全国性研究。数据来自最初招募的44名女性，其中26名在截止日期前成功怀孕。7名女性使用了辅助生殖技术（ART）；6名女性违背神经科医生的建议停止了疾病修正治疗（DMT）；6名女性因MS复发、MRI检测到的炎症或DMT疗程之间有限的“机会窗口”而在尝试受孕过程中出现中断。
该研究阐明了女性受孕所采取的途径，即使她们接受相同的治疗且MS的临床表现相似。治疗神经科医生给出的关于洗脱期的建议存在差异。本文强调了一个现实问题，即由于缺乏“真实世界”数据，对于如何管理这些女性尚无明确的国际共识，因此CANPREG-MS的目标是提供此类真实世界数据。
