Sadovnick Dessa, Criscuoli Maria, Yee Irene, Carruthers Robert, Schabas Alice, Devonshire Virginia, Smyth Penelope
Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada/Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Mult Scler. 2023 Mar;29(3):407-414. doi: 10.1177/13524585221146270. Epub 2023 Jan 22.
There is increasing need for evidence-based data on reproduction for women with multiple sclerosis (MS). First-trimester (first 13 weeks) miscarriages are relatively common in the general population. It is therefore important to have information on the frequency with which this occurs in women with MS.
The Canadian Multiple Sclerosis Pregnancy Study (CANPREG-MS) is a prospective study on women with MS who are pregnant or actively trying to conceive. As far as we are aware, this is the first study on miscarriages for this population that takes into account each woman's entire pregnancy history (i.e. before and after the MS diagnosis as well as during enrollment in CANPREG-MS).
There were 208 pregnancies during the study and 36 resulted in first-trimester miscarriage for a rate of 17.31%, within the expected range of 15%-20% for the general population.
CANPREG-MS provides real world data that there does not appear to be an increase in first-trimester miscarriages for women with MS. This information will be helpful to women with MS and their healthcare providers.
对于患有多发性硬化症（MS）的女性而言，基于证据的生殖数据需求日益增长。在普通人群中，孕早期（前13周）流产相对常见。因此，了解MS女性发生这种情况的频率很重要。
加拿大多发性硬化症妊娠研究（CANPREG-MS）是一项针对怀孕或积极尝试受孕的MS女性的前瞻性研究。据我们所知，这是第一项针对该人群流产情况的研究，该研究考虑了每位女性的整个妊娠史（即MS诊断之前和之后以及参与CANPREG-MS期间）。
研究期间共有208次妊娠，其中36次导致孕早期流产，流产率为17.31%，在普通人群预期的15%-20%范围内。
CANPREG-MS提供了真实世界的数据，表明MS女性孕早期流产似乎没有增加。这一信息将对MS女性及其医疗服务提供者有所帮助。
