Conway S P, Gillies D R, Docherty A
University Department of Paediatrics and Child Health, General Infirmary, Leeds.
Arch Dis Child. 1987 Dec;62(12):1252-6. doi: 10.1136/adc.62.12.1252.
In an open study 120 consecutively admitted premature babies of 32 weeks' gestation or less, were randomised to receive weekly intramuscular injections of human normal immunoglobulin (50 mg/kg). There was no significant difference between the number of babies in the treated and untreated groups who had at least one episode of infection, but the total number of infective episodes was substantially less in the treated group (n = 22) compared with 40 in the non-treated group. Three babies died from overwhelming infection and three babies developed necrotising enterocolitis, all in the group that had not been treated. Serum IgG concentrations were significantly higher in the treated group by the age of 2 weeks but remained consistently below those of full term babies of similar postnatal age. Administration of human immunoglobulin may decrease the severity of infection in premature babies, but alternative regimens may be more successful.
在一项开放性研究中，120名连续收治的妊娠32周及以下的早产儿被随机分组，接受每周一次的肌肉注射人正常免疫球蛋白（50毫克/千克）。在至少有一次感染发作的治疗组和未治疗组婴儿数量上没有显著差异，但治疗组的感染发作总数（n = 22）明显少于未治疗组的40次。三名婴儿死于严重感染，三名婴儿发生坏死性小肠结肠炎，均在未治疗组。治疗组在2周龄时血清IgG浓度显著更高，但一直低于出生后年龄相似的足月儿。给予人免疫球蛋白可能会降低早产儿感染的严重程度，但其他方案可能更有效。
