Conway S P, Ng P C, Howel D, Maclain B, Gooi H C
Department of Infectious Disease, Seacroft Hospital, UK.
Vox Sang. 1990;59(1):6-11. doi: 10.1111/j.1423-0410.1990.tb02105.x.
Sixty-six pre-term infants of less than 30 weeks gestation consecutively admitted to either of two neonatal intensive care units were randomized to receive routine intensive care only or prophylactic intravenous immunoglobulin, 200 mg/kg body weight at 3-weekly intervals in addition to routine intensive care. Eleven babies, 6 in the control group and 5 in the treatment group, were withdrawn from the trial due to early death from extreme prematurity (7 babies), early return to the referring hospital (3 babies), and elective treatment with intravenous immunoglobulin for severe congenital septicaemia (1 baby). Of the 55 who remained in the trial, significantly fewer babies in the treatment group had infection, 8 compared to 17 (p = 0.01). This difference was not significant when blood-culture-proven septicaemia only was considered, 8 compared to 14 (p = 0.09). Twenty-seven (84%) of 32 blood-culture-positive episodes of infection were caused by coagulase-negative staphylococci. Serum IgG was significantly higher with treatment and achieved levels comparable to those of normal full-term babies at the same post-natal age.
连续入住两个新生儿重症监护病房之一的66名孕周小于30周的早产儿被随机分组，一组仅接受常规重症监护，另一组除常规重症监护外，每隔3周接受一次200mg/kg体重的预防性静脉注射免疫球蛋白。11名婴儿退出试验，其中对照组6名，治疗组5名，原因包括极早产儿早期死亡（7名婴儿）、早期转回转诊医院（3名婴儿）以及因严重先天性败血症接受静脉注射免疫球蛋白的选择性治疗（1名婴儿）。在继续参与试验的55名婴儿中，治疗组发生感染的婴儿明显较少，分别为8例和17例（p = 0.01）。仅考虑血培养确诊的败血症时，这种差异不显著，分别为8例和14例（p = 0.09）。32次血培养阳性的感染发作中，27次（84%）由凝固酶阴性葡萄球菌引起。治疗后血清IgG显著升高，在相同出生后年龄达到与正常足月儿相当的水平。
