Emerg Infect Dis. 2021 Oct;27(10):2535-2543. doi: 10.3201/eid2710.211394. Epub 2021 Aug 5.
We conducted an international multicenter retrospective cohort study, PregOuTCOV, to examine the effect of gestational age at time of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on obstetric and neonatal outcomes. We included all singleton pregnancies with a live fetus at 10 weeks' gestation in which pregnancy outcomes were known. The exposed group consisted of patients infected with SARS-CoV-2, whereas the unexposed group consisted of all remaining patients during the same period. Primary outcomes were defined as composite adverse obstetric outcomes and composite adverse neonatal outcomes. Of 10,925 pregnant women, 393 (3.60%) were infected with SARS-CoV-2 (exposed group). After matching for possible confounders, we identified statistically significant increases in the exposed group of composite adverse obstetric outcomes at >20 weeks' gestation and of composite adverse neonatal outcomes at >26 weeks' gestation (p<0.001). Vaccination programs should target women early in pregnancy or before conception, if possible.
我们开展了一项国际性多中心回顾性队列研究（PregOuTCOV），以探究感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）时的孕龄对产科和新生儿结局的影响。我们纳入了所有在 10 孕周时存在存活胎儿且已知妊娠结局的单胎妊娠。暴露组由感染 SARS-CoV-2 的患者组成，而未暴露组则由同期所有其余患者组成。主要结局定义为复合不良产科结局和复合不良新生儿结局。在 10925 名孕妇中，有 393 名（3.60%）感染了 SARS-CoV-2（暴露组）。在对可能的混杂因素进行匹配后，我们发现 >20 孕周时的复合不良产科结局和 >26 孕周时的复合不良新生儿结局在暴露组中显著增加（p<0.001）。如果可能的话，疫苗接种计划应针对妊娠早期或受孕前的妇女。
