HepaCAM 塑造星形胶质细胞的领地，稳定缝隙连接偶联，并影响神经元的兴奋性。
HepaCAM shapes astrocyte territories, stabilizes gap-junction coupling, and influences neuronal excitability.
机构信息
Department of Neurobiology, University of California Los Angeles, Los Angeles, CA 90095-1763, USA.
出版信息
Neuron. 2021 Aug 4;109(15):2365-2367. doi: 10.1016/j.neuron.2021.07.010.
PMID:34352210
Abstract
How astrocytes form non-overlapping territories within synaptic neuropil is not understood. In this issue of Neuron, Baldwin et al. (2021) report that the cell adhesion molecule hepaCAM shapes murine astrocyte territories and that hepaCAM loss impairs gap-junction cell coupling and the balance between synaptic excitation and inhibition.
摘要
星形胶质细胞如何在突触神经原纤维内形成不重叠的领地尚不清楚。在本期《神经元》杂志中，Baldwin 等人（2021）报告称细胞黏附分子 hepaCAM 塑造了小鼠星形胶质细胞的领地，hepaCAM 的缺失会损害缝隙连接细胞偶联以及突触兴奋和抑制之间的平衡。
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