Soones Tacara, Ombres Rachel, Escalante Carmen
Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1465, Houston, TX 77030, USA.
J Geriatr Oncol. 2022 Mar;13(2):125-131. doi: 10.1016/j.jgo.2021.07.006. Epub 2021 Aug 2.
Up to 70% of older adults report fatigue after a cancer diagnosis. For many of these patients, cancer-related fatigue (CRF) persists for years after cancer treatment and is associated with significant disability. Despite this, little has been written on the diagnosis and management of CRF in older adults. To address this gap, we performed a narrative review of the literature on CRF in older adults and used literature from the general population when evidence was lacking to provide guidance to clinical providers on how to tailor care to this population. We recommend evidence-based options for evaluating CRF and address their limitations in the assessment of older adults. We also provide guidance and a treatment algorithm on evaluating CRF using the Comprehensive Geriatrics Assessment. Lastly, we present evidence for the use of non-pharmacologic and pharmacologic therapies in the management of CRF in older adults.
高达70%的老年人在被诊断患有癌症后会出现疲劳症状。对于其中许多患者来说，癌症相关疲劳（CRF）在癌症治疗后会持续数年，并与严重的残疾相关。尽管如此，关于老年患者CRF的诊断和管理的文献却很少。为了填补这一空白，我们对关于老年患者CRF的文献进行了叙述性综述，并在缺乏证据时使用来自普通人群的文献，为临床医生提供如何为该人群量身定制护理的指导。我们推荐基于证据的评估CRF的方法，并阐述它们在评估老年人时的局限性。我们还提供了使用综合老年评估来评估CRF的指导和治疗算法。最后，我们展示了在老年患者CRF管理中使用非药物和药物疗法的证据。
