美国成年人慢性支气管炎与血镉水平相互作用对心肌梗死患病率的影响：2005-2016 年全国健康和营养调查。
Interaction Between Chronic Bronchitis and Blood Cadmium Levels on the Prevalence of Myocardial Infarction in US Adults: The National Health and Nutritional Examination Survey, 2005-2016.
机构信息
Florida International University, Robert Stempel College of Public Health & Social Work, Department of Biostatistics, Miami, Florida (Dr Ibrahimou, Ms Sun); Vanderbilt University Medical Center, Department of Health Policy and Medicine, Nashville, Tennessee (Dr Aliyu); Florida International University, Robert Stempel College of Public Health & Social Work, Department of Environmental Health Sciences, Miami, Florida (Dr Guilarte); University of New South Wales, School of Psychiatry, Faculty of Medicine, Sydney, Australia (Ms Azim).
出版信息
J Occup Environ Med. 2021 Dec 1;63(12):1087-1092. doi: 10.1097/JOM.0000000000002346.
OBJECTIVE
To explore the interaction between chronic bronchitis and blood cadmium on the prevalence of myocardial infarction.
METHODS
We used weighted US-NHANES data. Multivariate survey logistic regression was used to examine the associations between myocardial infarction, cadmium concentration and chronic bronchitis. Adjusted odds ratios, 95% confidence intervals were computed.
RESULTS
There was a significant interaction (OR=1.33, CI = [1.01, 1.74]) between chronic bronchitis and blood cadmium level on the presence of myocardial infarction. For 1 μg/L increase in cadmium level, people with chronic bronchitis had 1.65 (1.24 × 1.33) times the odds of having myocardial infarction, while those without chronic bronchitis would be only 1.24 times as likely having the outcome (OR = 1.24, CI = [1.05, 1.46]).
CONCLUSION
Findings highlights the role of chronic bronchitis on the relationship between blood cadmium concentration and myocardial infarction. Prospective cohort designs are needed to confirm these findings.
目的
探讨慢性支气管炎与血镉对心肌梗死患病率的交互作用。
方法
我们使用加权美国国家健康和营养调查（NHANES）数据。采用多变量调查逻辑回归分析方法，检验心肌梗死、血镉浓度与慢性支气管炎之间的关系。计算调整后的比值比（OR）及其 95%置信区间（CI）。
结果
慢性支气管炎和血镉水平之间存在显著的交互作用（OR=1.33，CI=[1.01, 1.74]），与心肌梗死的发生有关。血镉水平每增加 1μg/L，患有慢性支气管炎的人群发生心肌梗死的几率是没有慢性支气管炎人群的 1.65 倍（OR=1.65，CI=[1.24, 1.33]），而没有慢性支气管炎的人群发生心肌梗死的几率仅为 1.24 倍（OR=1.24，CI=[1.05, 1.46]）。
结论
研究结果强调了慢性支气管炎在血镉浓度与心肌梗死之间关系中的作用。需要前瞻性队列设计来证实这些发现。
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