New Mexico State University, Las Cruces, NM, 88003, USA.
Burrell College of Osteopathic Medicine, 3501 Arrowhead Dr, Las Cruces, NM, 88003, USA.
Environ Sci Pollut Res Int. 2022 Oct;29(48):73480-73491. doi: 10.1007/s11356-022-20982-9. Epub 2022 May 27.
Metals, arsenic, and polycyclic aromatic hydrocarbons (PAHs) have all been linked to respiratory diseases. Chronic bronchitis, which is a form of chronic obstructive pulmonary disease (COPD), is a major public health concern and source of morbidity and mortality in the US. The purpose of this study was to analyze the correlation of 14 urinary metals (antimony, barium, cadmium, cesium, cobalt, lead, manganese, mercury, molybdenum, strontium, thallium, tin, tungsten, uranium), seven species of arsenic, and seven forms of polycyclic aromatic hydrocarbon (PAH) concentrations and chronic bronchitis in the US population. A cross-sectional analysis using three datasets from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2016 in adults, aged 20 years and older. Chronic bronchitis was determined using a self-questionnaire from the NHANES dataset. A specialized weighted complex survey design analysis package was used to analyze NHANES data. Multivariate logistic regression models were used to determine the correlation between urinary metals, arsenic, PAHs, and chronic bronchitis. Models were adjusted for lifestyle and demographic factors. A total of 4186 participants were analyzed; 49.8% were female and 40.5% were non-Hispanic White. All seven types of PAHs showed a positive association with chronic bronchitis (1-hydroxynaphthalene odds ratio (OR): 1.559, 95% confidence interval (CI): 1.271-1.912; 2-hydroxynaphthalene OR: 2.498, 95% CI: 1.524-4.095; 3-hydroxyfluorene OR: 2.752, 95% CI: 2.100-3.608; 2-hydroxyfluorene OR: 3.461, 95% CI: 2.438-4.914; 1-hydroxyphenanthrene OR: 2.442, 95% CI: 1.515-3.937; 1-hydroxypyrene OR: 2.828, 95% CI: 1.728-4.629; 2 & 3-hydroxyphenanthrene OR: 3.690, 95% CI: 2.309-5.896). Of the metals, only urinary cadmium showed a statistically significant positive association (OR: 2.435, 95% CI: 1.401-4.235) with chronic bronchitis. No other metals or arsenic were correlated with chronic bronchitis. Seven forms of urinary PAHs, cadmium, and several demographic factors were associated with chronic bronchitis.
金属、砷和多环芳烃 (PAHs) 都与呼吸道疾病有关。慢性支气管炎是一种慢性阻塞性肺疾病 (COPD)，是美国主要的公共卫生问题和发病率及死亡率的来源。本研究旨在分析美国人群中 14 种尿金属（锑、钡、镉、铯、钴、铅、锰、汞、钼、锶、铊、锡、钨、铀）、七种砷物种和七种多环芳烃 (PAH) 浓度与慢性支气管炎的相关性。使用 2011 年至 2016 年期间国家健康和营养检查调查 (NHANES) 中的三个数据集对成年人进行了横断面分析，年龄在 20 岁及以上。慢性支气管炎通过 NHANES 数据集的自我问卷确定。使用专门的加权复杂调查设计分析软件包分析 NHANES 数据。使用多变量逻辑回归模型确定尿金属、砷、PAH 与慢性支气管炎之间的相关性。模型调整了生活方式和人口统计学因素。共分析了 4186 名参与者；49.8%为女性，40.5%为非西班牙裔白人。所有七种类型的 PAH 均与慢性支气管炎呈正相关（1-羟基萘的比值比 (OR)：1.559，95%置信区间 (CI)：1.271-1.912；2-羟基萘的 OR：2.498，95% CI：1.524-4.095；3-羟基芴的 OR：2.752，95% CI：2.100-3.608；2-羟基芴的 OR：3.461，95% CI：2.438-4.914；1-羟基菲的 OR：2.442，95% CI：1.515-3.937；1-羟基芘的 OR：2.828，95% CI：1.728-4.629；2 和 3-羟基菲的 OR：3.690，95% CI：2.309-5.896）。在金属中，只有尿镉与慢性支气管炎呈统计学显著正相关（OR：2.435，95% CI：1.401-4.235）。其他金属或砷与慢性支气管炎均无相关性。七种尿 PAH、镉和几个人口统计学因素与慢性支气管炎有关。
