日本（）物种低分子量海藻酸盐的制备及其肠道免疫刺激活性

Preparation and Intestinal Immunostimulating Activity of Low Molecular Weight Alginate from () Species in Japan.

作者信息

Suzuki Shiho, Ono Mariko, Toda Toshiya, Kitamura Shinichi

机构信息

1 Graduate School of Life and Environmental Sciences, Osaka Prefecture University.

2 International Polysaccharide Engineering (IPE) Inc. (Center for R&D of Bioresources, Osaka Prefecture University).

出版信息

J Appl Glycosci (1999). 2016 Feb 20;63(1):1-5. doi: 10.5458/jag.jag.JAG-2015_017. eCollection 2016.

DOI:10.5458/jag.jag.JAG-2015_017

PMID:34354474

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8114153/

Abstract

We studied the structure of alginates extracted from five commercial () species including three varieties (eight samples in all) harvested in Hokkaido, Japan. The algae used were var. var. var. , and (). These alginates have molar fractions of mannuronic acid ( ) ranging from 0.68 to 0.76 and weight average molecular weights ( s) ranging from 511,000 to 616,000. Alginate samples from both ( = 0.76) and ( = 0.68) showed intestinal immunological activity through Peyer's patch cells of C3H/HeJ mice. Low molecular weight alginate ( = 0.75, = 70,000) degraded using a wet pulverizing system showed higher activity than the native one.

摘要

我们研究了从五种商业（）藻类中提取的藻酸盐的结构，这些藻类包括在日本北海道收获的三个品种（共八个样本）。所使用的藻类为 var. var. var., 以及（）。这些藻酸盐的甘露糖醛酸（）摩尔分数在0.68至0.76之间，重均分子量（）在511,000至616,000之间。来自（ = 0.76）和（ = 0.68）的藻酸盐样品通过C3H/HeJ小鼠的派尔集合淋巴结细胞显示出肠道免疫活性。使用湿式粉碎系统降解的低分子量藻酸盐（ = 0.75， = 70,000）显示出比天然藻酸盐更高的活性。