Gu Jun-Nan, Yao Shuang, Cao Ying-Hao, Deng Sheng-He, Mao Fu-Wei, Jiang Hong-Yu, He Yang-Ting, Li Xin-Ying, Ke Song-Qing, Li Hui-Li, Li Hang, Liu Xing-Hua, Liu Hong-Li, Wang Ji-Liang, Wu Ke, Liu Li, Cai Kai-Lin
Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
Department of Epidemiology and Biostatistics, The Ministry of Education Key Lab of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
World J Gastrointest Surg. 2021 Jul 27;13(7):689-701. doi: 10.4240/wjgs.v13.i7.689.
At present, the value of lipid indicators in evaluating the prognosis of colorectal cancer is still relatively limited.
To evaluate the value of a novel parameter for colorectal cancer (CRC) prognosis scoring based on preoperative serum lipid levels.
Four key serum lipid factors, namely, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB), were detected. Two representative ratios, HDL-C-LDL-C ratio (HLR) and ApoA1-ApoB ratio (ABR) were calculated. The relationship of these parameters with the prognosis of CRC patients including progression-free survival (PFS) and overall survival (OS) was analyzed by Kaplan-Meier plot and Cox proportional hazards regression. A novel lipoprotein cholesterol-apolipoprotein (LA) score based on HLR and ABR was established and its value in prognosis evaluation for CRC patients was explored.
Multivariate Cox proportional hazards regression analysis of PFS and OS showed that HDL-C, ApoA1, HLR, and ABR were positively associated with the prognosis of CRC patients. LA score was independently associated with a good prognosis in resectable CRC patients. Data processing of a dummy variable showed that the prognosis of patients with higher LA scores is better than that with lower LA scores.
The newly established LA score might serve as a better predictor of the prognosis of resectable CRC patients.
目前，脂质指标在评估结直肠癌预后方面的价值仍然相对有限。
评估基于术前血清脂质水平的一种新型结直肠癌（CRC）预后评分参数的价值。
检测四个关键血清脂质因子，即高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（ApoA1）和载脂蛋白B（ApoB）。计算两个代表性比值，即HDL-C-LDL-C比值（HLR）和ApoA1-ApoB比值（ABR）。通过Kaplan-Meier曲线和Cox比例风险回归分析这些参数与CRC患者预后的关系，包括无进展生存期（PFS）和总生存期（OS）。基于HLR和ABR建立了一种新型脂蛋白胆固醇-载脂蛋白（LA）评分，并探讨其在CRC患者预后评估中的价值。
对PFS和OS的多变量Cox比例风险回归分析表明，HDL-C、ApoA1、HLR和ABR与CRC患者的预后呈正相关。LA评分与可切除CRC患者的良好预后独立相关。虚拟变量的数据处理表明，LA评分较高患者的预后优于评分较低者。
新建立的LA评分可能是可切除CRC患者预后的更好预测指标。
