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第一掌骨巨大骨巨细胞瘤:一例报告及治疗趋势

Mammoth Giant Cell Tumor of the First Metacarpal: A Case Report and Management Trends.

作者信息

Agrawal Alok C, Verma Shilp, Kar Bikram, Sakale Harshal, Choudhary Ranjeet

机构信息

Orthopedics, All India Institute of Medical Sciences, Raipur, IND.

出版信息

Cureus. 2021 Jul 3;13(7):e16150. doi: 10.7759/cureus.16150. eCollection 2021 Jul.

Abstract

Giant cell tumor (GCT) is classically described as a locally aggressive, epiphyseo-metaphyseal osteolytic tumor occurring in young adults. They are mostly seen in long bones while some are also found in the iliac bone and spine and a very small proportion occurs in hand bones. Due to the rarity of GCT in metacarpal, there is a paucity of treatment options available. In an extensive literature search on PubMed, Embase, Medline, and Ovid from 2004 till date, very few cases were reported. The various treatment options available are intralesional curettage with or without adjuvant therapy, wide resection, free osteoarticular metatarsal transfer, and, occasionally, ray amputation may also be done. After simple curettage, a reasonably high recurrence rate also imposes comprehensive en-bloc excision, but still, there are many case reports of recurrence. Experience with a case of GCT of the whole first metacarpal extending from the carpometacarpal to the metacarpophalangeal joint is not thoroughly described in the literature. We hereby report a mammoth GCT of the first metacarpal treated by excision and reconstruction by free fibular graft and adjacent joint fusion with an excellent functional outcome at one-year follow-up.

摘要

骨巨细胞瘤(GCT)传统上被描述为一种发生于年轻人的局部侵袭性骨骺-干骺端溶骨性肿瘤。它们大多见于长骨,也有一些见于髂骨和脊柱,极少数发生于手部骨骼。由于掌骨中骨巨细胞瘤罕见,可供选择的治疗方案很少。在对2004年至今的PubMed、Embase、Medline和Ovid进行广泛文献检索时,报道的病例非常少。现有的各种治疗方案包括病灶内刮除术(有无辅助治疗)、广泛切除术、游离骨关节跖骨转移术,偶尔也可能进行射线截肢术。单纯刮除术后,较高的复发率也促使采用彻底的整块切除术,但仍有许多复发的病例报告。关于首例掌骨骨巨细胞瘤累及腕掌关节至掌指关节的病例经验,文献中并未详尽描述。我们在此报告一例通过游离腓骨移植切除及重建并进行相邻关节融合治疗的首例掌骨巨大骨巨细胞瘤,在一年随访时功能结果极佳。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97d7/8328844/1f17516a17b3/cureus-0013-00000016150-i01.jpg

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