Sarnaik Mubashira K, Modi Srimy, Pisipati Yasaswi, Vaidya Sarayoo, Syed Gaggatur Naqvi, Sange Aliya H, Srinivas Natasha, Sange Ibrahim
Internal Medicine, M S Ramaiah Medical College, Bangalore, IND.
Internal Medicine, K. J. Somaiya Medical College, Mumbai, IND.
Cureus. 2021 Jul 29;13(7):e16744. doi: 10.7759/cureus.16744. eCollection 2021 Jul.
Proton pump inhibitors (PPIs) are among the most extensively prescribed medications internationally for gastroesophageal reflux disease treatment and the prevention of gastrointestinal bleeding. Their efficiency, ease of availability, and low side effect profile offer several advantages over other treatment modalities. Long-term use and inappropriate prescribing habits have increased the presence of this class of drugs, prompting several studies to reassess their adverse effects. This article explored the possibility of a relationship between PPIs and cardiovascular adverse effects while highlighting the current prescription guidelines for PPIs. We further examined the need for more research into the etiology of PPI-related cardiovascular adverse effects and strategies to alleviate these risks.
质子泵抑制剂(PPIs)是国际上治疗胃食管反流病和预防胃肠道出血最广泛使用的药物之一。与其他治疗方式相比,它们的有效性、易获得性和低副作用具有诸多优势。长期使用和不恰当的处方习惯增加了这类药物的使用,促使多项研究重新评估其不良反应。本文探讨了质子泵抑制剂与心血管不良反应之间存在关联的可能性,同时强调了当前质子泵抑制剂的处方指南。我们进一步研究了对质子泵抑制剂相关心血管不良反应的病因进行更多研究的必要性以及减轻这些风险的策略。