Molla Md Maruf Ahmed, Yeasmin Mahmuda, Ghosh Asish Kumar, Nafisa Tasnim, Islam Md Khairul, Saif-Ur-Rahman K M
Department of Virology National Institute of Laboratory Medicine and Referral Center Dhaka Bangladesh.
Department of Virology Dhaka Medical College Dhaka Bangladesh.
Health Sci Rep. 2021 Jul 30;4(3):e344. doi: 10.1002/hsr2.344. eCollection 2021 Sep.
It is postulated that molecular methods along with mathematical modeling can provide critical inference regarding epidemiological parameters, transmission dynamics, spatiotemporal characteristics, and intervention efficacy. Hence, studying molecular epidemiology of human immunodeficiency virus (HIV)-1 infection, especially in resource-limited settings and with a large diaspora of the migrant population such as that of Bangladesh, is of paramount importance. The purpose of this systematic review was to concisely present and discuss the findings from previous studies conducted in Bangladesh regarding HIV-1 subtype prevalence.
Articles were retrieved from six publicly available databases regarding HIV-1 molecular epidemiology using keywords HIV, HIV-1, subtype(s), Bangladesh, and any combination of aforementioned keywords using Boolean operators. A total of 14 articles were downloaded and screened for suitability. Finally, five studies, containing pooled sequences from 317 individuals, were included in this systematic review.
Results revealed a preponderance of subtype C among HIV-1 infected population (51.10%), followed by circulating recombinant form (CRF)_07BC (15.46%), CRF_01AE (5.68%), A1 (4.73%), CRF_02AG (3.47%), G (3.15%), CRF_62BC (2.84%), B (2.21%), and other subtypes and recombinant forms in small percentages. Subtype C was largely predominant in intravenous drug users as well as female sex workers, whereas the migrant population exhibited a diverse subtype including rare recombinant forms, largely due to their travel in the Middle East and other South East Asian countries.
With the number of HIV-1 infections increasing among the general population and a steady increase in the migrant population, molecular epidemiological data are required to curb the progression of the HIV-1 epidemic in Bangladesh.
据推测，分子方法与数学建模能够为流行病学参数、传播动态、时空特征及干预效果提供关键推断。因此，研究人类免疫缺陷病毒（HIV）-1感染的分子流行病学，尤其是在资源有限的环境以及像孟加拉国那样有大量移民人口散居的情况下，至关重要。本系统评价的目的是简要呈现并讨论此前在孟加拉国开展的关于HIV-1亚型流行情况的研究结果。
使用关键词HIV、HIV-1、亚型、孟加拉国以及上述关键词的任意组合并通过布尔运算符，从六个公开可用的数据库中检索有关HIV-1分子流行病学的文章。共下载了14篇文章并筛选其适用性。最后，五项包含来自317名个体的汇总序列的研究被纳入本系统评价。
结果显示，在HIV-1感染人群中C亚型占主导（51.10%），其次是流行重组型（CRF）_07BC（15.46%）、CRF_01AE（5.68%）、A1（4.73%）、CRF_02AG（3.47%）、G（3.15%）、CRF_62BC（2.84%）、B（2.21%），其他亚型和重组型占比很小。C亚型在静脉吸毒者以及女性性工作者中占主要地位，而移民人群呈现出多种亚型，包括罕见的重组型，这主要是由于他们前往中东和其他东南亚国家旅行。
随着普通人群中HIV-1感染人数的增加以及移民人口的稳步增长，需要分子流行病学数据来遏制孟加拉国HIV-1疫情的发展。
