Zwierzchowski Lech, Ostrowska Małgorzata, Żelazowska Beata, Bagnicka Emilia
Institute of Genetics and Animal Biotechnology Polish Academy of Sciences (IGAB PAS), Jastrzębiec, Poland.
Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Lublin, Poland.
Anim Biotechnol. 2023 Apr;34(2):225-235. doi: 10.1080/10495398.2021.1954934. Epub 2021 Aug 6.
In this study, novel single nucleotide polymorphisms (SNPs) were found in the 5'-regulatory regions (promoters) of the bovine glucose transporter (GT) genes and These polymorphisms were shown to associate with certain milk production traits in HF cows, including milk yield, milk composition, and somatic cell count. It was shown that the SNP g.-671C > G (NC_037336.1: g.72224078C > G) in the gene could be an effective marker of cattle production traits and that genotypes CC and CG are associated with the best productivity. The polymorphisms found in the gene promoter also influenced milk production traits in HF cows, albeit to a lesser extent, and we propose that these polymorphisms could be useful as genetic markers for milk production traits in marker-assisted selection (MAS); however, this must be confirmed on larger populations of cattle. In addition, the presence of polymorphisms within promoter regions appears to affect the expression of GT genes in the cow mammary gland and modify transcription factor (TF) binding capacity.
在本研究中，在牛葡萄糖转运蛋白（GT）基因的5'调控区（启动子）中发现了新的单核苷酸多态性（SNP），并且这些多态性与荷斯坦奶牛的某些产奶性状相关，包括产奶量、乳成分和体细胞计数。研究表明，该基因中的SNP g.-671C＞G（NC_037336.1: g.72224078C＞G）可能是牛生产性状的有效标记，基因型CC和CG与最佳生产力相关。在该基因启动子中发现的多态性也影响了荷斯坦奶牛的产奶性状，尽管程度较小，并且我们提出这些多态性可作为标记辅助选择（MAS）中产奶性状的遗传标记；然而，这必须在更大规模的牛群中得到证实。此外，启动子区域内多态性的存在似乎会影响GT基因在奶牛乳腺中的表达并改变转录因子（TF）结合能力。
