Discipline of Pharmaceutical Sciences, School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Int J Pharm Pract. 2021 Oct 18;29(5):406-415. doi: 10.1093/ijpp/riab049.
Drug-food interactions (DFIs) are a problem in clinical practice as they can alter the bioavailability of drugs and nutrients and may lead to various adverse effects. Healthcare professionals (HCPs) play a significant role in counselling patients and preventing these interactions. Knowledge, attitudes and practices (KAPs) regarding DFIs are, therefore, vital to ensure that they carry out their role efficiently. This review maps evidence on KAPs of HCPs regarding DFIs and highlights gaps for further research.
A systematic literature search for the period from 1990 to 2018 was done using Google Scholar, PubMed and ScienceDirect. Keywords such as 'knowledge, attitudes, practices, healthcare professionals, drug-food interactions' in combination with the Boolean operator (AND) were used. Articles published only in English that described KAPs of HCPs relating to DFIs were included.
Twelve studies were included in this review. Inadequate knowledge was observed among the HCPs as they were unable to identify important DFIs. The HCPs had a positive attitude towards acquiring knowledge, reporting and counselling patients on DFIs. Most of the medical residents felt that they were inadequately trained on DFIs and over half believed that DFIs were only slightly important in clinical practice.
Deficits exist in the KAPs of HCPs regarding DFIs. An educational intervention targeting HCPs is recommended. Further research assessing the KAPs of the HCPs is required as the small number of studies conducted was a limitation.
药物-食物相互作用（DFIs）是临床实践中的一个问题，因为它们会改变药物和营养素的生物利用度，并可能导致各种不良反应。医疗保健专业人员（HCPs）在为患者提供咨询和预防这些相互作用方面发挥着重要作用。因此，了解 HCPs 对 DFI 的知识、态度和实践（KAPs）至关重要，以确保他们能够有效地发挥作用。本综述旨在绘制 HCPs 对 DFI 的 KAP 证据图，并突出进一步研究的差距。
使用 Google Scholar、PubMed 和 ScienceDirect 对 1990 年至 2018 年期间的文献进行了系统检索。使用了“知识、态度、实践、医疗保健专业人员、药物-食物相互作用”等关键词，并结合布尔运算符（AND）。仅纳入描述 HCPs 与 DFI 相关的 KAPs 的英文文章。
本综述共纳入 12 项研究。研究发现 HCPs 的知识不足，他们无法识别重要的 DFI。HCPs 对获取 DFI 知识、报告和为患者提供咨询持积极态度。大多数医学住院医师认为他们对 DFI 的培训不足，超过一半的人认为 DFI 在临床实践中仅略重要。
HCPs 在 DFI 的 KAPs 方面存在缺陷。建议针对 HCPs 进行教育干预。由于进行的研究数量有限，需要进一步研究评估 HCPs 的 KAPs。
