Balaban Ugur, Balaban Tuba Yildiz, Cakir Burcu Kelleci
Department of Clinical Pharmacy, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye.
Ankara Gazi Mustafa Kemal Occupational and Environmental Diseases Hospital, Ankara, Türkiye.
BMC Med Educ. 2025 Jul 1;25(1):934. doi: 10.1186/s12909-025-07518-8.
Food-drug interactions (FDIs) can affect drug efficacy and patient safety, potentially leading to therapeutic failures or adverse events. Despite their clinical relevance, FDIs are often overlooked in practice. This study aimed to assess FDI knowledge among Turkish healthcare professionals (HCPs) and identify factors associated with knowledge proficiency.
A web-based, cross-sectional survey was conducted between February and March 2025 among HCPs, including pharmacists, physicians, nurses, and other allied HCPs. FDI knowledge was assessed using a validated 21-item scale, with scores categorized as low (0-5), moderate (6-10), good (11-15), and very good (16-21). Multivariable quantile regression analysis was performed to determine factors associated with higher FDI knowledge scores.
A total of 418 HCPs participated, with a median FDI knowledge score of 13 (interquartile range [IQR]: 7) out of 21. Pharmacists had the highest median score of 15 (5), followed by physicians with 12 (6), nurses with 10 (7), and other allied HCPs with 10 (6) (p < 0.001). Level of knowledge varied significantly across professions, with 25.4% of participants categorized as "very good," 36.4% as "good," 29.2% as "moderate," and 9.1% as "low." Multivariable regression identified profession and higher education level as significant predictors of FDI knowledge. Pharmacists had significantly higher scores across all percentiles (p < 0.001). HCPs with a doctorate or equivalent specialty demonstrated significantly higher scores at the 25th (p = 0.011), 50th (p < 0.001), and 75th (p = 0.008) percentiles. Similarly, those with a master's degree had significantly higher scores at the median percentile (p < 0.001). Sex, age, and years of professional experience were not significant determinants (p > 0.05).
This study reveals substantial variability in FDI knowledge among HCPs, with pharmacists demonstrating the highest proficiency. However, critical knowledge gaps remain across all professional groups. Addressing these gaps is critical for optimizing pharmacotherapy and ensuring patient safety. Given the risks of unrecognized FDIs, structured educational interventions are urgently needed to improve clinical decision-making and reduce preventable potential FDIs related to adverse events.
食物-药物相互作用（FDIs）会影响药物疗效和患者安全，可能导致治疗失败或不良事件。尽管其具有临床相关性，但在实际操作中，FDIs常常被忽视。本研究旨在评估土耳其医疗保健专业人员（HCPs）对FDIs的知识掌握情况，并确定与知识水平相关的因素。
于2025年2月至3月间，对包括药剂师、医生、护士及其他相关医疗保健专业人员在内的HCPs开展了一项基于网络的横断面调查。使用经过验证的21项量表评估FDIs知识，分数分为低（0 - 5分）、中（6 - 10分）、良好（11 - 15分）和非常好（16 - 21分）。进行多变量分位数回归分析以确定与较高FDIs知识得分相关的因素。
共有418名HCPs参与，21分制下FDIs知识得分中位数为13分（四分位间距[IQR]：7分）。药剂师得分中位数最高，为15分（5分），其次是医生，为12分（6分），护士为10分（7分），其他相关医疗保健专业人员为10分（6分）（p < 0.001）。不同职业的知识水平差异显著，25.4%的参与者被归类为“非常好”，36.4%为“良好”，29.2%为“中等”，9.1%为“低”。多变量回归分析确定职业和高等教育水平是FDIs知识的重要预测因素。药剂师在所有百分位数上得分均显著更高（p < 0.001）。拥有博士学位或同等专业学位的HCPs在第25百分位数（p = 0.011）、第50百分位数（p < 0.001）和第75百分位数（p = 0.008）得分显著更高。同样，拥有硕士学位的人员在中位数百分位数上得分显著更高（p < 0.001）。性别、年龄和专业经验年限不是显著的决定因素（p > 0.05）。
本研究揭示了HCPs对FDIs知识的显著差异，药剂师表现出最高的水平。然而，所有专业群体中仍存在关键的知识差距。弥补这些差距对于优化药物治疗和确保患者安全至关重要。鉴于未被识别的FDIs存在风险，迫切需要开展结构化教育干预，以改善临床决策并减少与不良事件相关的可预防的潜在FDIs。
