Abou-Rjeileh Ursula, Contreras G Andres
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Antioxidants (Basel). 2021 Jul 7;10(7):1090. doi: 10.3390/antiox10071090.
Lipid mobilization in adipose tissues, which includes lipogenesis and lipolysis, is a paramount process in regulating systemic energy metabolism. Reactive oxygen and nitrogen species (ROS and RNS) are byproducts of cellular metabolism that exert signaling functions in several cellular processes, including lipolysis and lipogenesis. During lipolysis, the adipose tissue generates ROS and RNS and thus requires a robust antioxidant response to maintain tight regulation of redox signaling. This review will discuss the production of ROS and RNS within the adipose tissue, their role in regulating lipolysis and lipogenesis, and the implications of antioxidants on lipid mobilization.
脂肪组织中的脂质动员，包括脂肪生成和脂肪分解，是调节全身能量代谢的一个至关重要的过程。活性氧和氮物种（ROS和RNS）是细胞代谢的副产物，在包括脂肪分解和脂肪生成在内的多个细胞过程中发挥信号传导功能。在脂肪分解过程中，脂肪组织会产生活性氧和氮物种，因此需要强大的抗氧化反应来维持对氧化还原信号的严格调控。本综述将讨论脂肪组织中活性氧和氮物种的产生、它们在调节脂肪分解和脂肪生成中的作用，以及抗氧化剂对脂质动员的影响。
