Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstr. 1, 13088 Berlin, Germany.
MFSZ GmbH, Sternstr 28, 01139 Dresden, Germany.
Biomolecules. 2021 Jul 12;11(7):1017. doi: 10.3390/biom11071017.
Vitamin D has a steroid- and an anabolic-resembling chemical structure. Vitamin D is essential for many processes in the human body after hydroxylation.
To investigate the impact of 25-hydroxy-vitamin D plasma concentrations on the blood parameters number of erythrocytes, hematocrit, mean corpuscular hemoglobin and mean corpuscular volume.
Serial assessments were done in 290 patients with multiple sclerosis and repeated after a mean interval of 245 days. A recommendation for vitamin D supplementation was given in case of a concentration lower than 20 ng/mL combined with a prescription of a formulation containing vitamin D but not vitamin K.
There was a fall of vitamin D in 119 subjects and a rise in 164, while no change appeared in 7 participants. When vitamin D values went down between both assessments moments, the computed increase of mean corpuscular haemoglobin was significantly lower compared with the rise of mean corpuscular haemoglobin associated with a vitamin D elevation. When vitamin D declined, the computed fall of mean corpuscular volume fall was significantly lower compared with the decrease of mean corpuscular volume, when vitamin D rose. Positive correlations were found between differences of vitamin D and mean corpuscular haemoglobin, respectively mean corpuscular volume. Inverse relations appeared between disparities of vitamin D and erythrocytes, respectively haematocrit.
The elevation of vitamin D plasma levels provides enhanced preconditions for a better tissue oxygenation on a cellular level.
维生素 D 具有类固醇和合成代谢的化学结构。维生素 D 在羟化后对人体许多过程至关重要。
研究 25-羟维生素 D 血浆浓度对红细胞数量、红细胞压积、平均红细胞血红蛋白和平均红细胞体积等血液参数的影响。
对 290 例多发性硬化症患者进行了连续评估，并在平均 245 天后重复评估。如果浓度低于 20ng/ml 且同时伴有维生素 D 但不含维生素 K 的制剂处方，则建议补充维生素 D。
在 119 名受试者中维生素 D 下降，在 164 名受试者中维生素 D 上升，而在 7 名受试者中维生素 D 没有变化。当两次评估之间的维生素 D 值下降时，与维生素 D 升高相关的平均红细胞血红蛋白的计算增加明显低于与维生素 D 降低相关的平均红细胞血红蛋白的增加。当维生素 D 下降时，与维生素 D 升高时相比，平均红细胞体积下降的计算下降明显较低。发现维生素 D 和平均红细胞血红蛋白之间存在差异，分别与平均红细胞体积之间存在正相关。维生素 D 和红细胞之间存在反比关系，分别是红细胞压积。
提高维生素 D 血浆水平为细胞水平的组织更好地供氧提供了更好的前提条件。
