Institute of Haematology, Davidoff Cancer Centre, Rabin Medical Centre, Petah Tikva, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Acta Haematol. 2023;146(3):206-213. doi: 10.1159/000529356. Epub 2023 Feb 1.
We aimed to assess the natural annual trends in the levels of haemoglobin, haematocrit, and mean corpuscular volume (MCV) in a population of adults, together with the influence of different clinical parameters on these trends.
A retrospective analysis was carried out on data from a large cohort of subjects attending a screening centre in Israel. For each subject, the yearly average change of haemoglobin, haematocrit, and MCV was calculated. Statistical analysis was performed for the whole cohort and for different subgroups.
The study included 3,551 subjects. The average annual rates of decline were found to be -0.0550 g/dL (95% confidence interval [CI] -0.0590 g/dL to -0.0503 g/dL) and -0.097% (95% CI -0.112% to -0.083%) for haemoglobin and haematocrit, respectively. An average annual increase in the MCV level by 0.184 fL (95% CI 0.168 fL-0.200 fL) was found. Among men, the rate of decline in haemoglobin was found to be twice as high compared with women -0.06 g/dL versus -0.03 g/dL, respectively (p = 0.0063). In a multivariate analysis, gender remained the only parameter significantly associated with the annual decline of haemoglobin (p = 0.0001).
An annual average decrease in the levels of haemoglobin and haematocrit together with an annual increase in MCV was found. These changes were more prominent in men.
我们旨在评估成年人中血红蛋白、红细胞压积和平均红细胞体积（MCV）水平的自然年度变化趋势，以及不同临床参数对这些趋势的影响。
对以色列一个筛查中心的大量受试者数据进行回顾性分析。对于每个受试者，计算血红蛋白、红细胞压积和 MCV 的年平均变化值。对整个队列和不同亚组进行了统计分析。
该研究共纳入 3551 名受试者。发现血红蛋白和红细胞压积的年平均下降率分别为-0.0550 g/dL（95%置信区间[CI]：-0.0590 g/dL 至-0.0503 g/dL）和-0.097%（95% CI：-0.112%至-0.083%）。发现 MCV 水平平均每年增加 0.184 fL（95% CI：0.168 fL-0.200 fL）。与女性相比，男性血红蛋白的下降速度更快，分别为-0.06 g/dL 与-0.03 g/dL（p = 0.0063）。在多变量分析中，性别仍然是唯一与血红蛋白年度下降显著相关的参数（p = 0.0001）。
发现血红蛋白和红细胞压积水平呈年均下降趋势，MCV 呈年均上升趋势。这些变化在男性中更为明显。
