Department of Physical and Inorganic Chemistry, Universitat Rovira i Virgili, Carrer de Marcel∙lí Domingo, s/n, 43007 Tarragona, Spain.
Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain.
Biosensors (Basel). 2021 Jul 9;11(7):230. doi: 10.3390/bios11070230.
Surface-enhanced Raman spectroscopy (SERS) merges nanotechnology with conventional Raman spectroscopy to produce an ultrasensitive and highly specific analytical tool that has been exploited as the optical signal read-out in a variety of advanced applications. In this feature article, we delineate the main features of the intertwined relationship between SERS and nucleic acids (NAs). In particular, we report representative examples of the implementation of SERS in biosensing platforms for NA detection, the integration of DNA as the biorecognition element onto plasmonic materials for SERS analysis of different classes of analytes (from metal ions to microorgniasms) and, finally, the use of structural DNA nanotechnology for the precise engineering of SERS-active nanomaterials.
表面增强拉曼光谱（SERS）将纳米技术与传统拉曼光谱相结合，产生了一种超灵敏、高特异性的分析工具，已被用作各种先进应用中的光学信号读出。在这篇专题文章中，我们阐述了 SERS 与核酸（NAs）之间相互交织关系的主要特征。特别是，我们报告了 SERS 在核酸检测生物传感平台中的代表性应用实例，将 DNA 作为生物识别元件整合到等离子体材料中，用于分析不同类别的分析物（从金属离子到微生物），以及最后，利用结构 DNA 纳米技术精确工程 SERS 活性纳米材料。
