Advanced Photonics Center, School of Electronic Science and Engineering, Southeast University, 210096, Nanjing, China; Medical Devices, International Iberian Nanotechnology Laboratory - INL, 4715-330, Braga, Portugal.
Medical Devices, International Iberian Nanotechnology Laboratory - INL, 4715-330, Braga, Portugal; Escola de Ciências, University of Minho, Campus Gualtar, 4710-057, Braga, Portugal.
Biosens Bioelectron. 2022 May 15;204:114075. doi: 10.1016/j.bios.2022.114075. Epub 2022 Feb 9.
Cancer is the second leading cause of death worldwide. Early diagnosis and personalization of treatment have become effective routes to control the increasing mortality rate. Since cancer is a genetic disease, there is a great demand for novel techniques to detect tumor nucleic acids (NAs) with increased sensitivity. In recent years, surface enhanced Raman spectroscopy (SERS) emerged as a popular technique for biosensing in cancer theranostics. Combined with molecular probes, SERS allows ultrasensitive and multiplex detection of tumor-derived NAs, with great potential for clinical cancer detection and subtyping. In this review, we summarize and compare the various strategies for designing SERS-based NA sensors, focusing on the mechanism of sensing, followed by their representative applications to cancer theranostics in recent 5 years, as well as future challenges for clinical translation. The review is aimed to provide basic guidelines for engineering SERS-based NA sensors, according to the specific clinical cancer application.
癌症是全球第二大致死原因。早期诊断和个性化治疗已成为控制死亡率不断上升的有效途径。由于癌症是一种遗传性疾病，因此非常需要新的技术来提高灵敏度检测肿瘤核酸（NAs）。近年来，表面增强拉曼光谱（SERS）作为癌症治疗中的生物传感的一种热门技术而出现。与分子探针结合使用，SERS 可以实现对肿瘤来源的 NAs 的超灵敏和多重检测，具有很大的临床癌症检测和亚型分析的潜力。在这篇综述中，我们总结和比较了设计基于 SERS 的 NA 传感器的各种策略，重点介绍了传感机制，然后介绍了它们在最近 5 年中在癌症治疗中的代表性应用，以及临床转化的未来挑战。这篇综述旨在根据具体的临床癌症应用，为基于 SERS 的 NA 传感器的工程设计提供基本指南。
