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哥伦比亚人群呼吸道病毒感染的抗生素处方

Antibiotic Prescriptions for Respiratory Tract Viral Infections in the Colombian Population.

作者信息

Machado-Duque Manuel E, García Diego Arturo, Emura-Velez Melissa Hiromi, Gaviria-Mendoza Andrés, Giraldo-Giraldo Claudia, Machado-Alba Jorge E

机构信息

Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira 660003, Colombia.

Grupo de Investigación Biomedicina, Fundación Universitaria Autónoma de las Américas, Pereira 660003, Colombia.

出版信息

Antibiotics (Basel). 2021 Jul 16;10(7):864. doi: 10.3390/antibiotics10070864.

Abstract

Antimicrobials are frequently inappropriately prescribed for the management of upper respiratory tract infections (URTIs); therefore, the frequency of antibiotic prescriptions for patients with viral URTIs was assessed in this study. A cross-sectional study, including ambulatory patients diagnosed with viral URTI, was conducted, and records of antimicrobial prescriptions were obtained. Sociodemographic, clinical (diagnostic), and pharmacological (antimicrobial) variables were assessed. Through multivariate analysis, variables associated with the use of antibiotics for viral infections were identified. A total of 341,182 patients with viral URTIs were identified. The patients, who were from 26 different departments of Colombia, had a mean age of 29.7 ± 23.5 years and a female predominance of 58.7% ( = 200,195). The most frequent viral infections were as follows: acute rhinopharyngitis (common cold) ( = 206,211; 60.4%); unspecified acute tonsillitis ( = 27,432; 8.0%); and acute pharyngitis ( = 26,411; 7.7%). A total of 24.8% of the patients ( = 84,453) received a prescription for antibiotics, predominantly penicillins ( = 61,871; 18.1%) and cephalosporins ( = 10,926; 3.2%). Patients treated in Atlántico, Valle, and Risaralda departments, along with those older than 5 years, were more likely to receive antibiotics for the treatment of viral infections. Antibiotics are frequently prescribed for the management of URTIs, which is considered an inappropriate practice due to a lack of clinical benefits, increased generation of antimicrobial resistance, and a risk of adverse reactions due to the use of medications that patients do not require. Drug utilization studies are a great tool for monitoring how antibiotics are being used and planning interventions to improve their use.

摘要

抗菌药物常用于上呼吸道感染(URTIs)的治疗,但使用往往并不恰当;因此,本研究评估了病毒性URTIs患者的抗生素处方频率。开展了一项横断面研究,纳入诊断为病毒性URTIs的门诊患者,并获取抗菌药物处方记录。评估了社会人口统计学、临床(诊断)和药理学(抗菌药物)变量。通过多变量分析,确定了与病毒感染使用抗生素相关的变量。共识别出341182例病毒性URTIs患者。这些患者来自哥伦比亚的26个不同科室,平均年龄为29.7±23.5岁,女性占比58.7%(n = 200195)。最常见的病毒感染如下:急性鼻咽炎(普通感冒)(n = 206211;60.4%);未明确的急性扁桃体炎(n = 27432;8.0%);以及急性咽炎(n = 26411;7.7%)。共有24.8%的患者(n = 84453)接受了抗生素处方,主要是青霉素类(n = 61871;18.1%)和头孢菌素类(n = 10926;3.2%)。在大西洋省、山谷省和里萨拉尔达省接受治疗的患者,以及5岁以上的患者,更有可能接受抗生素治疗病毒感染。抗菌药物常用于URTIs的治疗,由于缺乏临床益处、增加抗菌药物耐药性的产生以及使用患者不需要的药物而导致不良反应的风险,这被认为是一种不恰当的做法。药物利用研究是监测抗生素使用情况和规划干预措施以改善其使用的重要工具。

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