School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China.
National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China.
Mar Drugs. 2021 Jul 14;19(7):395. doi: 10.3390/md19070395.
Three new metabolites, furobenzotropolones A, B (-) with unusual benzene and dihydrofuran moieties and 3-hydroxyepicoccone B (), together with seven known compounds (-) were obtained from the endophytic fungus MLY-3 isolated from the fresh leaf of mangrove plant collected from Zhuhai. Their structures were assigned by the analysis of UV, IR, NMR, and mass spectroscopic data. Compound was further confirmed by single-crystal X-ray diffraction experiment using Cu K radiation. In antioxidant activities in vitro, compounds , , , and showed promising DPPH· scavenging activity with IC values ranging from 14.7 to 29.3 µM. Compounds , , , , and exhibited promising potent activity in scavenging ABTS· with IC values in the range of 18-29.2 µM, which was stronger than that of the positive control ascorbic acid (IC = 33.6 ± 0.8 µM).
从珠海采集的红树林植物新鲜叶片中分离到的内生真菌 MLY-3 中，得到了三个新的代谢产物：呋喃苯并二氢呋喃酮 A、B（-）和 3-羟基表毛壳素 B（），它们具有不寻常的苯和二氢呋喃部分，以及七个已知化合物（-）。通过 UV、IR、NMR 和质谱光谱数据分析，确定了它们的结构。化合物 进一步通过单晶 X 射线衍射实验用 Cu K 辐射证实。在体外抗氧化活性中，化合物 、 、 、 和 对 DPPH·具有良好的清除活性，IC 值范围为 14.7-29.3 µM。化合物 、 、 、 和 对 ABTS·具有良好的清除活性，IC 值范围为 18-29.2 µM，比阳性对照抗坏血酸（IC = 33.6 ± 0.8 µM）更强。
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