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从红树林内生真菌 sp. CY-3 中发现具有β-葡萄糖苷酶抑制活性的次生代谢产物。

Secondary Metabolites with -Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus sp. CY-3.

机构信息

School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.

National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China.

出版信息

Mar Drugs. 2021 Aug 28;19(9):492. doi: 10.3390/md19090492.

DOI:10.3390/md19090492
PMID:34564154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8465095/
Abstract

Eight new compounds, including two sambutoxin derivatives (-), two highly oxygenated cyclopentenones (-), four highly oxygenated cyclohexenones (-), together with four known sambutoxin derivatives (-), were isolated from semimangrove endophytic fungus sp. CY-3, under the guidance of molecular networking. The structures of new isolates were elucidated by analysis of detailed spectroscopic data, ECD spectra, chemical hydrolysis, C NMR calculation, and DP4+ analysis. In bioassays, compounds - displayed better -glucosidase inhibitory activity than the positive control 1-deoxynojirimycin (IC = 80.8 ± 0.3 μM), and the IC value was in the range of 12.6 ± 0.9 to 57.3 ± 1.3 μM.

摘要

从半红树内生真菌 sp. CY-3 中，通过分子网络导向分离得到了 8 种新化合物，包括 2 种 sambutoxin 衍生物（-）、2 种高度氧化的环戊烯酮（-）、4 种高度氧化的环己烯酮（-），以及 4 种已知的 sambutoxin 衍生物（-）。通过详细的光谱数据分析、ECD 光谱、化学水解、C NMR 计算和 DP4+分析，阐明了新分离物的结构。在生物测定中，化合物 - 表现出比阳性对照 1-脱氧野尻霉素（IC = 80.8 ± 0.3 μM）更好的 -葡萄糖苷酶抑制活性，IC 值范围为 12.6 ± 0.9 至 57.3 ± 1.3 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/d3fc43dbc604/marinedrugs-19-00492-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/abb941082ed4/marinedrugs-19-00492-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/a34ea7dca0d8/marinedrugs-19-00492-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/3264e8a5c4ef/marinedrugs-19-00492-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/5e5af31d02dc/marinedrugs-19-00492-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/6d74e3711f1d/marinedrugs-19-00492-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/e04bfaf40795/marinedrugs-19-00492-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/c1e91ef314ad/marinedrugs-19-00492-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/d3fc43dbc604/marinedrugs-19-00492-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/abb941082ed4/marinedrugs-19-00492-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/a34ea7dca0d8/marinedrugs-19-00492-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/3264e8a5c4ef/marinedrugs-19-00492-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/5e5af31d02dc/marinedrugs-19-00492-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/6d74e3711f1d/marinedrugs-19-00492-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/e04bfaf40795/marinedrugs-19-00492-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/c1e91ef314ad/marinedrugs-19-00492-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2569/8465095/d3fc43dbc604/marinedrugs-19-00492-g008.jpg

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