School of Chemistry , Sun Yat-Sen University , Guangzhou 510275 , People's Republic of China.
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , People's Republic of China.
Org Lett. 2019 Dec 6;21(23):9633-9636. doi: 10.1021/acs.orglett.9b03796. Epub 2019 Nov 25.
A pair of enantiomeric indole diketopiperazine alkaloid dimers [(-)- and (+)-asperginulin A ( and )] with an unprecedented 6/5/4/5/6 pentacyclic skeleton were isolated from the mangrove endophytic fungus sp. SK-28. The enantiomeric dimers were separated by chiral-phase HPLC. Their structures including absolute configurations were elucidated by spectroscopic analysis, X-ray diffraction, and quantum chemical calculation. (+)-Asperginulin A () exhibited antifouling activity against the barnacle .
从红树林内生真菌 sp. SK-28 中分离得到一对对映异构的吲哚二酮哌嗪生物碱二聚体[(-)-和(+)-asperginulin A()和()]，具有前所未有的 6/5/4/5/6 个五环骨架。对映异构二聚体通过手性相高效液相色谱法分离。通过光谱分析、X 射线衍射和量子化学计算阐明了它们的结构，包括绝对构型。(+)-Asperginulin A()对藤壶表现出抗污活性。
