哮喘患者游离茶碱清除率的决定因素
Determinants of free theophylline clearance in asthma.
作者信息
Williams P E, Alwazir Y A, Littley M, Buss D C, John R, Campbell I A, Routledge P A, Lazarus J H
机构信息
Department of Medicine, University of Wales College of Medicine, Llandough Hospital, Penarth, South Glamorgan.
出版信息
Br J Clin Pharmacol. 1987 Nov;24(5):655-9. doi: 10.1111/j.1365-2125.1987.tb03225.x.
Abstract
- The free and total plasma and saliva concentrations of theophylline were measured during a dosing interval at steady state in nineteen asthmatic subjects receiving a once-daily theophylline preparation (Riker TCR-1). 2. Saliva theophylline clearance (mean +/- s.d. 5.8 +/- 2.1l h-1) was closely related to total plasma theophylline clearance (mean 3.6 +/- 1.2l h-1) (r = 0.958, n = 19, P less than 0.001). 3. Saliva theophylline clearance was closely related (r = 0.967, n = 19, P less than 0.001) and numerically very similar to the free plasma theophylline clearance (mean 5.8 +/- 1.9l h-1) (mean difference = 0.06 +/- 0.12 s.e. mean). 4. Free plasma theophylline clearance was significantly, although weakly, related to body weight and to the plasma free thyroxine concentration which together accounted for over 40 per cent of the variability in free clearance. 5. Theophylline administered for 2 weeks did not affect plasma free thyroxine (FT4) free tri-iodothyronine (FT3) or reverse tri-iodothyronine (rT3) concentrations compared with placebo.
摘要
- 在19名接受每日一次茶碱制剂（Riker TCR - 1）的哮喘患者的稳态给药间隔期间，测量了茶碱的游离和总血浆及唾液浓度。2. 唾液茶碱清除率（均值±标准差 5.8±2.1l/h）与总血浆茶碱清除率（均值 3.6±1.2l/h）密切相关（r = 0.958，n = 19，P＜0.001）。3. 唾液茶碱清除率密切相关（r = 0.967，n = 19，P＜0.001），并且在数值上与游离血浆茶碱清除率（均值 5.8±1.9l/h）非常相似（平均差异 = 0.06±0.12标准误均值）。4. 游离血浆茶碱清除率与体重以及血浆游离甲状腺素浓度显著相关，尽管相关性较弱，这两者共同解释了游离清除率中超过40%的变异性。5. 与安慰剂相比，给予茶碱2周并未影响血浆游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）或反三碘甲状腺原氨酸（rT3）的浓度。
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Theophylline kinetics in relation to age: the importance of smoking.茶碱动力学与年龄的关系：吸烟的重要性。
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Pharmacokinetics of theophylline in young and elderly subjects.
Gerontology. 1982;28(5):323-7. doi: 10.1159/000212549.
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Free and total plasma theophylline concentrations in chronic airflow obstruction.慢性气流阻塞患者血浆中游离和总茶碱浓度
Thorax. 1984 May;39(5):352-5. doi: 10.1136/thx.39.5.352.
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Influence of thyroid function on theophylline kinetics.
Clin Pharmacol Ther. 1984 Nov;36(5):634-40. doi: 10.1038/clpt.1984.233.
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Steady-state pharmacokinetics and effects of a new once-daily, slow-release theophylline capsule preparation in asthma.一种新型每日一次缓释茶碱胶囊制剂在哮喘中的稳态药代动力学及效果
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