腺苷可使人体冠状动脉出现短暂扩张。
Adenosine causes transient dilatation of coronary arteries in man.
作者信息
Watt A H, Penny W J, Singh H, Routledge P A, Henderson A H
机构信息
Department of Pharmacology, University of Wales College of Medicine, Heath Park, Cardiff.
出版信息
Br J Clin Pharmacol. 1987 Nov;24(5):665-8. doi: 10.1111/j.1365-2125.1987.tb03227.x.
Abstract
We investigated the effects of i.v. adenosine on coronary blood flow in 10 normal subjects undergoing investigation for chest pain. Coronary flow transiently doubled after greater than or equal to 3.5 mg adenosine without increase in perfusion pressure, systolic load or inotropic state at a constant, paced heart rate. The data provide direct evidence that adenosine dilates coronary arteries in man. The transience of the effect suggests a possible role for adenosine in repeated estimations of coronary flow reserve.
摘要
我们研究了静脉注射腺苷对10名因胸痛接受检查的正常受试者冠状动脉血流的影响。在恒定的起搏心率下，静脉注射大于或等于3.5毫克腺苷后，冠状动脉血流短暂增加一倍，而灌注压、收缩期负荷或心肌收缩状态均未增加。这些数据提供了腺苷可扩张人体冠状动脉的直接证据。这种效应的短暂性表明腺苷在重复评估冠状动脉血流储备中可能发挥作用。
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