Shek L L, Godolphin W, Spinelli J J
Department of Pathology, Vancouver General Hospital, B.C., Canada.
Br J Cancer. 1987 Dec;56(6):825-9. doi: 10.1038/bjc.1987.298.
The relationship to survival after first recurrence of oestrogen receptor (ER), nodal status and TNM stage at diagnosis, and treatment for advanced disease was studied in 457 females whose primary breast cancer was diagnosed in 1975 to 1981. Receptor concentration was the most important predictor of post-recurrence survival, with some additional information conveyed by nodal status. ER predicted survival after recurrence independently of nodal status, clinical stage or mode of therapy. Response to endocrine therapy is only a facet of the generally favourable prognosis of ER positive patients, rather than the sole explanation.
对1975年至1981年期间确诊为原发性乳腺癌的457名女性患者，研究了雌激素受体（ER）首次复发后与生存的关系、诊断时的淋巴结状态和TNM分期以及晚期疾病的治疗情况。受体浓度是复发后生存的最重要预测因素，淋巴结状态也能传达一些额外信息。ER独立于淋巴结状态、临床分期或治疗方式预测复发后的生存情况。对内分泌治疗的反应只是ER阳性患者总体预后良好的一个方面，而非唯一解释。
