Maynard P V, Davies C J, Blamey R W, Elston C W, Johnson J, Griffiths K
Br J Cancer. 1978 Dec;38(6):745-8. doi: 10.1038/bjc.1978.282.
A series of 300 patients presenting consecutively with primary operable breast cancer has been studied. A significant correlation was found between oestrogen-receptor (ER) content and histological grade: the better-differentiated tumours rarely lacked receptor. This correlation was significant only in women defined as post-menopausal. Data on early recurrence of disease indicate a worse prognosis for women in whom primary tumours are ER-.
对连续收治的300例原发性可手术乳腺癌患者进行了研究。发现雌激素受体（ER）含量与组织学分级之间存在显著相关性：分化较好的肿瘤很少缺乏受体。这种相关性仅在绝经后女性中显著。疾病早期复发的数据表明，原发性肿瘤ER阴性的女性预后较差。
