Toxicological Effects of Roundup on Reproduction.

Herbicide use has increased dramatically since 2001, particularly Roundup. Effective in agricultural practice, Roundup adversely affects non-target organisms, including reproductive and endocrine systems. We exposed fruit flies, , to either Roundup Ready to Use, containing pelargonic acid and glyphosate, or Roundup Super Concentrate, that includes glyphosate and POEA, at sublethal concentrations. Both Roundup formulations reduced ovary volume with fewer mature oocytes, most adversely at the highest concentration tested. Flies exposed within 2 h of eclosion were affected more than at 4 h, suggesting a critical period of increased ovarian sensitivity. These results support multi-species evidence that glyphosate-based herbicides interfere with normal development of the reproductive systems of non-target organisms.