Ekins B R, Watanabe A S
Am J Hosp Pharm. 1978 Mar;35(3):268-77.
Acute digoxin poisoning, its recognition and management, are reviewed. The uses of syrup of ipecac, gastric lavage, activated charcoal, cholestyramine, colestipol, edetate sodium and cathartics as measures to terminate the drug exposure are discussed. Measures to hasten digoxin elimination, such as the use of furosemide, hemodialysis and digoxin-specific antibodies are reviewed. Supportive management may include treatment with atropine, phenytoin, lidocaine, propranolol, glucose, insulin and sodium polystyrene sulfonate. Proper management of digoxin poisoning involves the use of standard decontamination procedures (emesis or gastric lavage). Activated charcoal is strongly recommended, followed by rapidly acting cathartics. Antiarrhythmic therapy usually involves atropine sulfate and phenytoin sodium.
本文综述了急性地高辛中毒及其识别与处理方法。讨论了使用吐根糖浆、洗胃、活性炭、考来烯胺、考来替泊、依地酸钠和泻药作为终止药物暴露的措施。回顾了加速地高辛消除的措施，如使用呋塞米、血液透析和地高辛特异性抗体。支持性治疗可能包括使用阿托品、苯妥英钠、利多卡因、普萘洛尔、葡萄糖、胰岛素和聚苯乙烯磺酸钠进行治疗。地高辛中毒的正确处理包括使用标准的去污程序（催吐或洗胃）。强烈推荐使用活性炭，随后使用速效泻药。抗心律失常治疗通常包括硫酸阿托品和苯妥英钠。
