Department of Structural Biology, Jacobs School of Medicine and Biological Sciences, University at Buffalo, Buffalo, New York, USA.
Department of Structural Biology, Jacobs School of Medicine and Biological Sciences, University at Buffalo, Buffalo, New York, USA.
J Biol Chem. 2021 Sep;297(3):101047. doi: 10.1016/j.jbc.2021.101047. Epub 2021 Aug 4.
The study of natural products provides exciting opportunities for the discovery of novel biologically active molecules and biosynthetic pathways. Recently, Yuan and colleagues described 30 cyclic depsipeptides that are biosynthesized by proteins encoded by three distinct gene clusters in the marine fungus, Beauveria felina. Genetic and biochemical studies confirmed the involvement of nonribosomal peptide synthetases in the production of multiple compounds, some of which inhibit Zika virus replication.
天然产物的研究为发现新型生物活性分子和生物合成途径提供了令人兴奋的机会。最近，袁博士及其同事描述了 30 种环二肽，这些环二肽是由海洋真菌拟青霉中三个不同基因簇编码的蛋白质生物合成的。遗传和生化研究证实了非核糖体肽合成酶在多种化合物的产生中的作用，其中一些化合物能抑制寨卡病毒的复制。
