Medical Laboratory Analysis Department, College of Health Sciences, Cihan University of Sulaimaniya, Kurdistan Region, Sulaimaniya, Iraq.
College of Veterinary Medicine, University of Sulaimani, Sulaimaniyah, Iraq.
Cell Commun Signal. 2022 Jun 3;20(1):81. doi: 10.1186/s12964-022-00880-w.
Balanced cell death and survival are among the most important cell development and homeostasis pathways that can play a critical role in the onset or progress of malignancy steps. Anastasis is a natural cell recovery pathway that rescues cells after removing the apoptosis-inducing agent or brink of death. The cells recuperate and recover to an active and stable state. So far, minimal knowledge is available about the molecular mechanisms of anastasis. Still, several involved pathways have been explained: recovery through mitochondrial outer membrane permeabilization, caspase cascade arrest, repairing DNA damage, apoptotic bodies formation, and phosphatidylserine. Anastasis can facilitate the survival of damaged or tumor cells, promote malignancy, and increase drug resistance and metastasis. Here, we noted recently known mechanisms of the anastasis process and underlying molecular mechanisms. Additionally, we summarize the consequences of anastatic mechanisms in the initiation and progress of malignancy, cancer cell metastasis, and drug resistance. Video Abstract.
平衡的细胞死亡和存活是最重要的细胞发育和体内平衡途径之一，它们在恶性肿瘤发生或进展的步骤中起着关键作用。复苏是一种自然的细胞恢复途径，可在去除凋亡诱导剂或接近死亡时挽救细胞。细胞恢复并恢复到活跃和稳定的状态。到目前为止，关于复苏的分子机制的知识还很少。尽管如此，已经解释了几个涉及的途径：通过线粒体外膜通透性的恢复、半胱天冬酶级联的阻滞、修复 DNA 损伤、凋亡小体的形成和磷脂酰丝氨酸。复苏可以促进受损或肿瘤细胞的存活，促进恶性肿瘤的发生，并增加耐药性和转移。在这里，我们注意到了最近已知的复苏过程的机制和潜在的分子机制。此外，我们总结了复苏机制在恶性肿瘤的发生和进展、癌细胞转移和耐药性中的作用。视频摘要。
