Bouezzedine Fidaa, El Baba Ranim, Haidar Ahmad Sandy, Herbein Georges
Pathogens & Inflammation/EPILAB Laboratory, EA 4266, University of Franche-Comté, 25000 Besançon, France.
Department of Virology, CHU Besançon, 25030 Besançon, France.
Cancers (Basel). 2023 Oct 15;15(20):4994. doi: 10.3390/cancers15204994.
Prostate cancer is the most commonly diagnosed malignancy and the sixth leading cause of cancer death in men worldwide. Chromosomal instability (CIN) and polyploid giant cancer cells (PGCCs) have been considered predominant hallmarks of cancer. Recent clinical studies have proven the association of CIN, aneuploidy, and PGCCs with poor prognosis of prostate cancer (PCa). Evidence of HCMV transforming potential might indicate that HCMV may be involved in PCa.
Herein, we underline the role of the high-risk HCMV-DB and -BL clinical strains in transforming prostate epithelial cells and assess the molecular and cellular oncogenic processes associated with PCa.
Oncogenesis parallels a sustained growth of "" or CTP cells that highly express Myc and EZH2, forming soft agar colonies and displaying stemness as well as mesenchymal features, hence promoting EMT as well as PGCCs and a spheroid appearance.
HCMV-induced Myc and EZH2 upregulation coupled with stemness and EMT traits in IE1-expressing CTP might highlight the potential role of HCMV in PCa development and encourage the use of anti-EZH2 and anti-HCMV in PCa treatment.
前列腺癌是全球男性中最常被诊断出的恶性肿瘤，也是癌症死亡的第六大主要原因。染色体不稳定性（CIN）和多倍体巨癌细胞（PGCCs）被认为是癌症的主要特征。最近的临床研究证实了CIN、非整倍体和PGCCs与前列腺癌（PCa）预后不良之间的关联。人巨细胞病毒（HCMV）具有转化潜能的证据可能表明HCMV可能与PCa有关。
在此，我们强调高危HCMV-DB和-BL临床菌株在转化前列腺上皮细胞中的作用，并评估与PCa相关的分子和细胞致癌过程。
肿瘤发生与高度表达Myc和EZH2的“”或CTP细胞的持续生长平行，形成软琼脂集落，并表现出干性以及间充质特征，从而促进上皮-间质转化（EMT）以及PGCCs和细胞集落样外观。
HCMV诱导的Myc和EZH2上调，以及在表达IE1的CTP细胞中的干性和EMT特征，可能突出了HCMV在PCa发展中的潜在作用，并鼓励在PCa治疗中使用抗EZH2和抗HCMV药物。
