Dou Aixia, Fang Jing
Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Columbia, SC 29208, USA.
Cancers (Basel). 2021 Jul 27;13(15):3772. doi: 10.3390/cancers13153772.
Accumulating studies highlight a critical role of myeloid cells in cancer biology and therapy. The myeloid cells constitute the major components of tumor microenvironment (TME). The most studied tumor-associated myeloid cells (TAMCs) include monocytes, tumor-associated macrophages (TAMs), dendritic cells (DCs), cancer-related circulating neutrophils, tumor-associated neutrophils (TANs), and myeloid-derived suppressor cells (MDSCs). These heterogenous myeloid cells perform pro-tumor or anti-tumor function, exerting complex and even opposing effects on all stages of tumor development, such as malignant clonal evolution, growth, survival, invasiveness, dissemination and metastasis of tumor cells. TAMCs also reshape TME and tumor vasculature to favor tumor development. The main function of these myeloid cells is to modulate the behavior of lymphocytes, forming immunostimulatory or immunosuppressive TME cues. In addition, TAMCs play a critical role in modulating the response to cancer therapy. Targeting TAMCs is vigorously tested as monotherapy or in combination with chemotherapy or immunotherapy. This review briefly introduces the TAMC subpopulations and their function in tumor cells, TME, angiogenesis, immunomodulation, and cancer therapy.
越来越多的研究凸显了髓系细胞在癌症生物学和治疗中的关键作用。髓系细胞构成了肿瘤微环境（TME）的主要成分。研究最多的肿瘤相关髓系细胞（TAMCs）包括单核细胞、肿瘤相关巨噬细胞（TAMs）、树突状细胞（DCs）、癌症相关循环中性粒细胞、肿瘤相关中性粒细胞（TANs）和髓系来源的抑制细胞（MDSCs）。这些异质性髓系细胞发挥促肿瘤或抗肿瘤功能，对肿瘤发展的各个阶段，如肿瘤细胞的恶性克隆进化、生长、存活、侵袭、播散和转移，产生复杂甚至相反的影响。TAMCs还重塑TME和肿瘤血管系统以促进肿瘤发展。这些髓系细胞的主要功能是调节淋巴细胞的行为，形成免疫刺激或免疫抑制的TME信号。此外，TAMCs在调节癌症治疗反应中起关键作用。针对TAMCs作为单一疗法或与化疗或免疫疗法联合使用正在进行大力测试。本综述简要介绍了TAMC亚群及其在肿瘤细胞、TME、血管生成、免疫调节和癌症治疗中的功能。
