Chun June Young, Kim Se Ik, Park Eun Young, Park Sang-Yoon, Koh Su-Jin, Cha Yongjun, Yoo Heon Jong, Joung Jae Young, Yoon Hong Man, Eom Bang Wool, Park Chul Min, Han Ji-Youn, Kim Miso, Lee Dae-Won, Kim Jae-Weon, Keam Bhumsuk, Lee Maria, Kim Tae Min, Choi Young Ju, Chang Yoon Jung, Lim Myong Cheol
Division of Infectious Disease, Department of Internal Medicine, National Cancer Center, Goyang 10408, Korea.
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea.
Cancers (Basel). 2021 Aug 1;13(15):3883. doi: 10.3390/cancers13153883.
Considering the high morbidity and mortality of Coronavirus disease 2019 (COVID-19) in patients with malignancy, they are regarded as a priority for COVID-19 vaccination. However, general vaccine uptake rates among cancer patients are known to be lower than in their healthy counterparts. Thus, we aimed to investigate the attitude and acceptance rates for the COVID-19 vaccine in cancer patients and identify predictive factors for vaccination that could be modified to increase vaccine uptake rates, via a paper-based survey (58 items over six domains). A total of 1001 cancer patients participated in this nationwide, multicenter survey between February and April 2021. We observed that 61.8% of respondents were willing to receive the COVID-19 vaccine. Positive predictive factors found to be independently associated with vaccination were male gender, older age, obesity, previous influenza vaccination history, absence of cancer recurrence, time since cancer diagnosis over 5 years, and higher EuroQol Visual Analogue Scale scores. Along with the well-known factors that are positively correlated with vaccination, here, we report that patients' disease status and current health status were also associated with their acceptance of the COVID-19 vaccination. Moreover, 91.2% of cancer patients were willing to be vaccinated if their attending physicians recommend it, indicating that almost 30% could change their decision upon physicians' recommendation. Unlike other factors, which are unmodifiable, physicians' recommendation is the single modifiable factor that could change patients' behavior. In conclusion, we firstly report that Korean cancer patients' acceptance rate of the COVID-19 vaccination was 61.8% and associated with disease status and current health status. Physicians should play a major role in aiding cancer patients' decision-making concerning COVID-19 vaccines.
鉴于2019冠状病毒病（COVID-19）在恶性肿瘤患者中的高发病率和死亡率，他们被视为COVID-19疫苗接种的优先对象。然而，已知癌症患者的总体疫苗接种率低于健康人群。因此，我们旨在通过一项纸质调查（涵盖六个领域的58个项目），调查癌症患者对COVID-19疫苗的态度和接受率，并确定可改变的疫苗接种预测因素，以提高疫苗接种率。2021年2月至4月期间，共有1001名癌症患者参与了这项全国性的多中心调查。我们观察到，61.8%的受访者愿意接种COVID-19疫苗。发现与疫苗接种独立相关的积极预测因素包括男性、年龄较大、肥胖、既往流感疫苗接种史、无癌症复发、癌症诊断后超过5年以及较高的欧洲五维健康量表视觉模拟评分。除了与疫苗接种呈正相关的众所周知的因素外，我们在此报告，患者的疾病状态和当前健康状态也与他们对COVID-19疫苗接种的接受程度有关。此外，如果主治医生建议，91.2%的癌症患者愿意接种疫苗，这表明近30%的患者可能会根据医生的建议改变决定。与其他不可改变的因素不同，医生的建议是唯一可改变的、能改变患者行为的因素。总之，我们首次报告韩国癌症患者对COVID-19疫苗的接受率为61.8%，且与疾病状态和当前健康状态相关。医生应在帮助癌症患者做出关于COVID-19疫苗的决策方面发挥主要作用。
