Department of Otorhinolaryngology-Head & Neck Surgery, Wonkwang University Hospital, Wonkwang University College of Medicine, Iksan 54538, Korea.
Department of Obstetrics and Gynecology, Hallym University College of Medicine, Anyang 14068, Korea.
Int J Environ Res Public Health. 2021 Jul 29;18(15):8046. doi: 10.3390/ijerph18158046.
The purpose of this study was to evaluate the association between female medical history and thyroid cancer. Data from the Korean Genome and Epidemiology Study were collected from 2004 to 2016. Among a total of 1303 participants with thyroid cancer and 106,602 control (non-thyroid cancer) participants, the odds ratios (ORs) with 95% confidence intervals (CIs) of hysterectomy, oophorectomy, use of oral contraceptives, and number of children were evaluated. The adjusted OR of hysterectomy for thyroid cancer was 1.73 (95% CI = 1.48-2.01, < 0.001) in the minimally adjusted model. The adjusted ORs for thyroid cancer were 1.89 (95% CI = 1.06-3.37, = 0.031), 0.89 (95% CI = 0.83-0.94, < 0.001), and 0.85 (95% CI = 0.73-0.99, = 0.040) for bilateral oophorectomy, number of children, and use of oral contraceptives, respectively, in the fully adjusted model. In the subgroup analysis, the adjusted ORs of bilateral oophorectomy were significant in the younger age (OR = 3.62, 95% CI = 1.45-9.03, = 0.006), while the number of children was significant in the older age (OR = 0.86, 95% CI = 0.80-0.93, < 0.001). The ORs of hysterectomy and bilateral oophorectomy were significantly higher in the thyroid cancer group in the younger age group. The adjusted ORs of the number of children were significantly low in the older age group.
本研究旨在评估女性病史与甲状腺癌之间的关联。数据来自 2004 年至 2016 年的韩国基因组和流行病学研究。在总共 1303 名甲状腺癌患者和 106602 名对照（非甲状腺癌）参与者中，评估了子宫切除术、卵巢切除术、口服避孕药使用和子女数量的比值比（OR）及其 95%置信区间（CI）。在最小调整模型中，子宫切除术与甲状腺癌的调整 OR 为 1.73（95%CI=1.48-2.01，<0.001）。在完全调整模型中，双侧卵巢切除术、子女数量和口服避孕药的甲状腺癌调整 OR 分别为 1.89（95%CI=1.06-3.37，=0.031）、0.89（95%CI=0.83-0.94，<0.001）和 0.85（95%CI=0.73-0.99，=0.040）。在亚组分析中，双侧卵巢切除术的调整 OR 在年龄较小的组中显著（OR=3.62，95%CI=1.45-9.03，=0.006），而子女数量在年龄较大的组中显著（OR=0.86，95%CI=0.80-0.93，<0.001）。子宫切除术和双侧卵巢切除术的 OR 在年龄较小的甲状腺癌组中显著较高。在年龄较大的组中，子女数量的调整 OR 显著较低。
