Department of Otorhinolaryngology-Head and Neck Surgery, Wonkwang University Hospital, Wonkwang University College of Medicine, Iksan 54538, Korea.
Department of Otolaryngology-Head and Neck Surgery, Hanyang University College of Medicine, Seoul 04763, Korea.
Int J Environ Res Public Health. 2021 Apr 29;18(9):4732. doi: 10.3390/ijerph18094732.
(1) Background: The purpose of this study was to determine the association among thyroid cancer, osteoporosis and fracture history. (2) Methods: The data collected from 2004 through 2016 for the Korean Genome and Epidemiology Study were retrieved. For a total of 1349 participants with thyroid cancer and 163,629 control participants, the odds ratios (ORs) with 95% confidence intervals (CIs) of osteoporosis and fracture history were evaluated using a logistic regression model. (3) Results: The adjusted ORs of osteoporosis comparing thyroid cancer with the control group were 1.41 (95% CI = 1.18-1.70, < 0.001) for all participants and 1.43 (95% CI = 1.19-1.71, < 0.001) for women. The adjusted ORs of fracture history comparing these two groups were not significantly associated within the entire group of participants, men only or women only. (4) Conclusions: The adjusted OR of osteoporosis was significantly higher than 1, comparing thyroid cancer with the control group, especially in women. The adjusted OR of fractures was not significantly higher than 1, comparing the thyroid cancer group with the control group.
(1) 背景：本研究旨在探讨甲状腺癌、骨质疏松症和骨折史之间的关联。
(2) 方法：从 2004 年至 2016 年，我们检索了韩国基因组和流行病学研究的数据。对患有甲状腺癌的 1349 名参与者和 163629 名对照参与者的数据进行分析，使用逻辑回归模型评估骨质疏松症和骨折史的比值比（OR）及其 95%置信区间（CI）。
(3) 结果：与对照组相比，所有参与者中甲状腺癌患者骨质疏松症的调整后 OR 为 1.41（95%CI=1.18-1.70，<0.001），女性为 1.43（95%CI=1.19-1.71，<0.001）。在整个参与者组、男性组或女性组中，两组间骨折史的调整后 OR 均无显著相关性。
(4) 结论：与对照组相比，甲状腺癌患者骨质疏松症的调整后 OR 明显高于 1，尤其是女性。与对照组相比，甲状腺癌组的骨折调整后 OR 并未显著升高。
