Hattevig G, Kjellman B, Björkstén B
Department of Paediatrics, University Hospital, Linköping, Sweden.
Clin Allergy. 1987 Nov;17(6):571-8. doi: 10.1111/j.1365-2222.1987.tb02053.x.
A group of eighty-six children followed from birth to 4 years of age and previously reported was now re-investigated at the age of 7 years. The prevalence of atopy/allergy was 15%. All of the children with current atopy/allergy had had previous manifestations during their first 4 years of life. No child was allergic to milk at the age of 7 years and only two of the six children with a previous allergy to eggs retained their allergy. No other children had developed allergies to milk or eggs. Only one of the eight children with an elevated level of IgE antibodies to egg white (RAST class 1 or more) during infancy still had increased concentrations of such antibodies. No child had developed an elevated level of IgE antibodies to egg white or milk after the first year of life. Clinical allergies to inhalants had increased from 1% at 4 years of age to 7% at 7 years. Children with elevated levels of IgE antibodies to inhalants had increased from 7% at 4 years of age to 10% at 7 years. The majority of them had had increased levels of IgE antibodies to egg white during infancy. The specificity of an elevated level of cord blood IgE, i.e. above 0.9 kU/l for predicting atopy/allergy during the first 7 years of life and for current atopy/allergy at 7 years of age were both 95%. The corresponding figures for presence of elevated levels of IgE antibodies to egg white (positive RAST) during infancy were 98 and 97%, respectively. The sensitivity of the cord blood IgE predictor was 14 and 17%, respectively and for a positive RAST to egg white during infancy 32 and 50%, respectively.
一组86名从出生到4岁一直在跟踪研究且之前已有报告的儿童，现在在7岁时再次接受调查。特应性/过敏的患病率为15%。所有目前患有特应性/过敏的儿童在其生命的头4年都曾有过相关表现。7岁时没有儿童对牛奶过敏，之前对鸡蛋过敏的6名儿童中只有2名仍有过敏症状。没有其他儿童对牛奶或鸡蛋产生过敏。婴儿期对蛋清IgE抗体水平升高（RAST分级为1级或更高）的8名儿童中，只有1名的此类抗体浓度仍处于升高状态。1岁以后没有儿童对蛋清或牛奶的IgE抗体水平升高。对吸入性物质的临床过敏从4岁时的1%增加到7岁时的7%。对吸入性物质IgE抗体水平升高的儿童从4岁时的7%增加到7岁时的10%。他们中的大多数在婴儿期对蛋清的IgE抗体水平升高。脐血IgE水平升高（即高于0.9 kU/l）预测生命头7年的特应性/过敏以及7岁时当前特应性/过敏的特异性均为95%。婴儿期蛋清IgE抗体水平升高（RAST阳性）的相应数字分别为98%和97%。脐血IgE预测指标的敏感性分别为14%和17%，婴儿期蛋清RAST阳性的敏感性分别为32%和50%。
