Department of Health Policy and Management, Chung Shan Medical University, Taichung 40201, Taiwan.
Department of Ophthalmology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Int J Environ Res Public Health. 2021 Jul 30;18(15):8106. doi: 10.3390/ijerph18158106.
Previous studies have demonstrated that patients with diabetic retinopathy (DR) have a higher prevalence of risk factors known to be associated with cardiovascular disease (CVD) We hypothesized that patients with more severe DR could have a higher relative risk of CVD.
To test this hypothesis, we used the National Health Insurance Research Database (NHIRD) to evaluate whether associations exist between DR and CVD. The data for this nationwide population-based retrospective cohort study were obtained from the NHIRD in Taiwan from 2001 to 2013. The assessed study outcome used was the incidence and other statistical analyses of CVD in patients with DR during a 13-year follow-up period.
Our findings obtained from 2001 to 2013 suggest that the incidence rates of CVD are 2.026 times that of diabetes mellitus (DM) without DR (95% C.I. = 1.876-2.187) and 2.75 times that of DM with DR (95% C.I. = 2.487-3.04) compared with the Non-DM group.
The relative risk of CVD in DR was greater than that in the Non-DM group for both men and women. Targeted monitoring of DM, especially the co-existence of diabetic retinopathy, is of utmost importance in the clinical care of the DM population.
先前的研究表明，患有糖尿病视网膜病变（DR）的患者具有更高的心血管疾病（CVD）相关已知危险因素的患病率。我们假设，DR 更严重的患者可能具有更高的 CVD 相对风险。
为了验证这一假设，我们使用国家健康保险研究数据库（NHIRD）来评估 DR 与 CVD 之间是否存在关联。这项全国性基于人群的回顾性队列研究的数据来自台湾的 NHIRD，时间为 2001 年至 2013 年。评估的研究结果是在 13 年的随访期间，DR 患者 CVD 的发生率和其他统计分析。
我们在 2001 年至 2013 年期间的发现表明，与无 DR 的糖尿病（DM）相比，CVD 的发病率为 2.026 倍（95%CI=1.876-2.187），与有 DR 的 DM 相比，CVD 的发病率为 2.75 倍（95%CI=2.487-3.04）。
对于男性和女性，DR 患者的 CVD 相对风险均高于非 DM 组。对 DM 尤其是糖尿病性视网膜病变共存的靶向监测对于 DM 人群的临床护理至关重要。
