Department of Legal Medicine and Bioethics, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 042122 Bucharest, Romania.
Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Int J Environ Res Public Health. 2021 Aug 3;18(15):8215. doi: 10.3390/ijerph18158215.
The main aim of this study was to test whether the use of mouthwash is associated with subtypes of squamous cell carcinoma of the head and neck (SCCHN) and to test the potential risk of SCCHN depending on the mouthwash use duration, frequency, or alcoholic content.
We performed a meta-analysis using Web of Science and Scopus databases to detect the risk change associated with mouthwash use depending on the alcohol content, duration and frequency of use, and anatomical location. We used a random-effects model with the Sidik-Jonkman estimator for effect size model measures.
We included 17 studies in the meta-analysis containing 17,085 cases and 20,032 controls. The risk difference for SCCHN between mouthwash users and non-users was minimal, with a value of -0.02 [-0.05, 0.01]. Alcoholic mouthwash use was associated with a minimal decrease in risk (of -0.01 [-0.07, 0.05]). Frequent usage of mouthwash was associated with a statistically significant risk increase for SCCHN but the risk increase was marginal (0.04, [0.01, 0.06]).
Overall, our study failed to show a statistically significant correlation between mouthwash use and the risk of SCCHN. The only statistically significant correlation that we could identify was between frequent usage and SCCHN, potentially caused by prolonged contact between some constituents of mouthwash (possibly alcohol) and the oral epithelium.
本研究的主要目的是检验使用漱口水是否与头颈部鳞状细胞癌（SCCHN）的亚型有关，并根据漱口水使用时间、频率或酒精含量检验 SCCHN 的潜在风险。
我们使用 Web of Science 和 Scopus 数据库进行荟萃分析，以检测与漱口水使用相关的风险变化，取决于酒精含量、使用持续时间、使用频率和解剖位置。我们使用随机效应模型和 Sidik-Jonkman 估计量进行效应量模型测量。
我们纳入了荟萃分析中的 17 项研究，共包含 17085 例病例和 20032 例对照。漱口水使用者和非使用者之间 SCCHN 的风险差异极小，值为-0.02[-0.05,0.01]。含酒精的漱口水使用与风险微小下降相关（-0.01[-0.07,0.05]）。频繁使用漱口水与 SCCHN 的风险增加具有统计学意义，但风险增加幅度较小（0.04，[0.01,0.06]）。
总体而言，我们的研究未能显示使用漱口水与 SCCHN 风险之间存在统计学显著相关性。我们唯一能够确定的统计学显著相关性是在频繁使用与 SCCHN 之间，这可能是由于漱口水的某些成分（可能是酒精）与口腔上皮之间的长时间接触引起的。
