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含酒精漱口水与口腔癌风险:探究两者关联

Alcohol-Containing Mouthwash and the Risk of Oral Cancer: Exploring the Association.

作者信息

Rao Karthik Nagaraja, Mehta Rupa, Dange Prajwal, Nagarkar Nitin M

机构信息

Department of Head and Neck Oncology, Sri Shankara Cancer Hospital and Research Center, Bangalore, India.

Department of Otorhinolaryngology and Head Neck Surgery, All India Institute of Medical Sciences, Raipur, India.

出版信息

Indian J Surg Oncol. 2024 Sep;15(3):553-556. doi: 10.1007/s13193-024-01948-4. Epub 2024 May 8.

DOI:10.1007/s13193-024-01948-4
PMID:39239449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11371988/
Abstract

Oral cavity and larynx cancers are generally associated with tobacco consumption, alcohol abuse or both. Mouthwashes are liquid antiseptic solutions that decrease the microbial load in the oral cavity. Alcohol is often used in mouthwashes for its antiseptic functions and as a carrier for some active ingredients, including menthol or thymol, helping them penetrate the plaque. There is some evidence for alcohol-containing mouthwash use which is associated with the potential risk of developing carcinoma of oral cavity. The results are inconclusive, as actual mouthwash use patterns may be inconsistent and cannot be easily quantified. Based on the available data, there is no sufficient evidence to accept the proposition that the use of mouthwashes containing alcohol can influence the development of oral cancer.

摘要

口腔癌和喉癌通常与吸烟、酗酒或两者都有关。漱口水是一种液体抗菌溶液,可减少口腔中的微生物数量。酒精常用于漱口水,因其具有抗菌功能,并作为薄荷醇或百里酚等一些活性成分的载体,帮助它们穿透牙菌斑。有一些证据表明,使用含酒精漱口水与患口腔癌的潜在风险有关。结果尚无定论,因为实际的漱口水使用模式可能不一致,且难以轻易量化。根据现有数据,没有足够的证据支持使用含酒精漱口水会影响口腔癌发生这一观点。

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引用本文的文献

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Does Mouthwash Use Affect Oral Cancer Risk? A Comprehensive Systematic Review and Meta-Analysis.使用漱口水会影响口腔癌风险吗?一项全面的系统评价和荟萃分析。
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本文引用的文献

1
Does the use of alcohol mouthwash increase the risk of developing oral cancer?使用含酒精的漱口水会增加罹患口腔癌的风险吗?
Evid Based Dent. 2022 Mar;23(1):28-29. doi: 10.1038/s41432-022-0236-0. Epub 2022 Mar 25.
2
Mouthwash Use and the Risk of Oral, Pharyngeal, and Laryngeal Cancer. A Meta-Analysis.漱口水使用与口腔、咽和喉癌风险的关系:一项荟萃分析。
Int J Environ Res Public Health. 2021 Aug 3;18(15):8215. doi: 10.3390/ijerph18158215.
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Head and neck squamous cell carcinoma.头颈部鳞状细胞癌
Nat Rev Dis Primers. 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3.
4
Mouthwash With Alcohol and Oral Carcinogenesis: Systematic Review and Meta-analysis.含酒精漱口水与口腔癌发生:系统评价和荟萃分析。
J Evid Based Dent Pract. 2020 Jun;20(2):101407. doi: 10.1016/j.jebdp.2020.101407. Epub 2020 Feb 5.
5
Alcohol-based mouthwash as a risk factor of oral cancer: A systematic review.含酒精的漱口水是口腔癌的一个风险因素:系统综述。
Med Oral Patol Oral Cir Bucal. 2020 Jan 1;25(1):e1-e12. doi: 10.4317/medoral.23085.
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The role of oral hygiene in head and neck cancer: results from International Head and Neck Cancer Epidemiology (INHANCE) consortium.口腔卫生在头颈癌中的作用:国际头颈癌流行病学(INHANCE)联盟的研究结果
Ann Oncol. 2016 Aug;27(8):1619-25. doi: 10.1093/annonc/mdw224. Epub 2016 May 27.
7
Mouthwash use and cancer of the head and neck: a pooled analysis from the International Head and Neck Cancer Epidemiology Consortium.使用漱口水与头颈癌:国际头颈癌流行病学联盟的汇总分析
Eur J Cancer Prev. 2016 Jul;25(4):344-8. doi: 10.1097/CEJ.0000000000000179.
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Mouthwash use and the prevention of plaque, gingivitis and caries.使用漱口水与预防牙菌斑、牙龈炎和龋齿。
Oral Dis. 2014 Jan;20 Suppl 1:1-68. doi: 10.1111/odi.12187.
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Alcohol-containing mouthwash and oral cancer--can epidemiology prove the absence of risk?含酒精漱口水与口腔癌——流行病学能否证明不存在风险?
Ann Agric Environ Med. 2012;19(3):609-10.
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Mouthwash and oral cancer risk quantitative meta-analysis of epidemiologic studies.漱口水与口腔癌风险:流行病学研究的定量荟萃分析
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