Broulik P D, Stĕpán J J, Pacovský V
3rd Department of Internal Medicine, Charles University Faculty of Medicine, Prague, Czechoslovakia.
Clin Chim Acta. 1987 Dec;170(2-3):195-200. doi: 10.1016/0009-8981(87)90128-8.
Urate metabolism was studied in 53 patients with primary hyperparathyroidism. They had compared to controls significantly higher serum urate and reduction of the clearance of urate. In 14 of the tested patients with primary hyperparathyroidism serum urate was increased above normal limits. Six months after parathyroidectomy serum urate fell significantly from 365.3 +/- 75.7 mumol/l to 265.7 +/- 48.3 mumol/l, in 26 patients where urate measurements were available before as well as after surgery. Serum urate levels in our patients with primary hyperparathyroidism did not correlate with clearance of urate. Levels of serum urate cannot be entirely explained by the decrease in renal clearance of urate. Serum urate levels did not correlate with severity of skeletal changes expressed by serum B-ALP and urinary excretion of hydroxyproline. These results suggest that parathormone does not increase the part of the urate pool coming from the nucleic acids of the increased bone metabolism.
对53例原发性甲状旁腺功能亢进患者的尿酸代谢进行了研究。与对照组相比，他们的血清尿酸显著升高，尿酸清除率降低。在14例接受检测的原发性甲状旁腺功能亢进患者中，血清尿酸升高至正常范围以上。在26例术前及术后均进行尿酸测量的患者中，甲状旁腺切除术后6个月，血清尿酸从365.3±75.7μmol/l显著降至265.7±48.3μmol/l。我们的原发性甲状旁腺功能亢进患者的血清尿酸水平与尿酸清除率无关。血清尿酸水平不能完全用尿酸肾清除率的降低来解释。血清尿酸水平与血清B-ALP和羟脯氨酸尿排泄所表达的骨骼变化严重程度无关。这些结果表明，甲状旁腺激素不会增加来自骨代谢增加的核酸的尿酸池部分。
