Pepersack T, Jabbour N, Fuss M, Karmali R, Van Geertruyden J, Corvilain J
Department of Internal Medicine, Brugmann University Hospital, Free University of Brussels, Belgium.
Nephron. 1989;53(4):349-52. doi: 10.1159/000185780.
Serum urate and the renal handling of urate were measured in 37 patients with primary hyperparathyroidism and in normal sex- and age-matched subjects. Serum urate was increased in the hyperparathyroid group compared to the control group (6.23 +/- 1.46 versus 4.64 +/- 1.24 mg/100 ml; p less than 0.005), whereas the fractional excretion of urate was decreased in hyperparathyroid patients compared to the controls (6.80 +/- 2.69 versus 8.73 +/- 3.47%; p less than 0.005). Twenty-four of these hyperparathyroid patients were studied 6 months after surgical correction of their disease. Serum urate decreased after surgery (5.14 +/- 1.65 mg/100 ml) compared to the preoperative state (5.92 +/- 1.46 mg/100 ml) and was no longer different from the normal values. The possible mechanisms of hyperuricemia associated with the hyperparathyroid state are discussed.
对37例原发性甲状旁腺功能亢进患者以及年龄和性别匹配的正常受试者测定了血清尿酸盐及尿酸盐的肾脏处理情况。与对照组相比，甲状旁腺功能亢进组的血清尿酸盐升高（6.23±1.46对4.64±1.24mg/100ml；p<0.005），而甲状旁腺功能亢进患者的尿酸排泄分数与对照组相比降低（6.80±2.69对8.73±3.47%；p<0.005）。其中24例甲状旁腺功能亢进患者在疾病手术矫正6个月后接受了研究。与术前状态（5.92±1.46mg/100ml）相比，术后血清尿酸盐降低（5.14±1.65mg/100ml），且与正常值不再有差异。讨论了与甲状旁腺功能亢进状态相关的高尿酸血症的可能机制。
