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槲皮素和杨梅素衍生物的区域选择性合成。

Regioselective Synthesis of Quercetin and Myricetin Derivatives.

作者信息

Pechinskii S V, Kuregyan A G, Oganesyan E T

机构信息

Medical Pharmaceutical Institute, Pyatigorsk Branch of Volgograd Medical State University, 357532 Pyatigorsk, Russia.

出版信息

Russ J Gen Chem. 2023;93(2):245-252. doi: 10.1134/S1070363223020032. Epub 2023 Mar 30.

DOI:10.1134/S1070363223020032
PMID:37016708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10062247/
Abstract

A regioselective method for the synthesis of esters of quercetin and myricetin at the hydroxy group in the position 3 was developed. As acids participating in the esterification reaction, 2-hydroxybenzoic (salicylic), 4-hydroxybenzoic, 2,6-dihydroxybenzoic, 3,4-dihydroxybenzoic (procatechuic), 3,4,5-trihydroxybenzoic (gallic) acids were used. A new series of quercetin and myricetin esters were obtained.

摘要

开发了一种在槲皮素和杨梅素3位羟基上合成酯的区域选择性方法。作为参与酯化反应的酸，使用了2-羟基苯甲酸（水杨酸）、4-羟基苯甲酸、2,6-二羟基苯甲酸、3,4-二羟基苯甲酸（原儿茶酸）、3,4,5-三羟基苯甲酸（没食子酸）。获得了一系列新的槲皮素和杨梅素酯。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c5b/10062247/1cddc64a9d9a/11176_2023_6147_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c5b/10062247/48c07367c5b9/11176_2023_6147_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c5b/10062247/1cddc64a9d9a/11176_2023_6147_Sch2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c5b/10062247/48c07367c5b9/11176_2023_6147_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c5b/10062247/1cddc64a9d9a/11176_2023_6147_Sch2_HTML.jpg

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