Zimmermann Gregor S, Ruether Tobias, von Ziegler Franz, Greif Martin, Tittus Janine, Schenzle Jan, Becker Christoph, Becker Alexander
Department of Internal Medicine I, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
Department of Psychiatry, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
J Clin Med. 2021 Jul 30;10(15):3382. doi: 10.3390/jcm10153382.
Pericardial adipose tissue (PAT), a visceral fat depot directly located to the heart, is associated with atherosclerotic and inflammatory processes. The extent of PAT is related to the prevalence of coronary heart disease and might be used for cardiovascular risk prediction. This study aimed to determine the effect of smoking on the extent of PAT.
We retrospectively examined 1217 asymptomatic patients (490 females, age 58.3 ± 8.3 years, smoker = 573, non-smoker = 644) with a multislice CT scanner and determined the PAT volume. Coronary risk factors were determined at inclusion, and a multivariate analysis was performed to evaluate the influence of smoking on PAT independent from accompanying risk factors.
The mean PAT volume was 215 ± 107 mL in all patients. The PAT volume in smokers was significantly higher compared to PAT volume in non-smokers (231 ± 104 mL vs. 201 ± 99 mL, = 0.03). Patients without cardiovascular risk factors showed a significantly lower PAT volume (153 ± 155 mL, < 0.05) compared to patients with more than 1 risk factor. Odds ratio was 2.92 [2.31, 3.61; < 0.001] for elevated PAT in smokers.
PAT as an individual marker of atherosclerotic activity and inflammatory burden was elevated in smokers. The finding was independent from metabolic risk factors and might therefore illustrate the increased inflammatory activity in smokers in comparison to non-smokers.
心包脂肪组织（PAT）是直接位于心脏的内脏脂肪库，与动脉粥样硬化和炎症过程相关。PAT的范围与冠心病的患病率有关，可能用于心血管风险预测。本研究旨在确定吸烟对PAT范围的影响。
我们使用多层CT扫描仪对1217例无症状患者（490例女性，年龄58.3±8.3岁，吸烟者573例，非吸烟者644例）进行回顾性检查，并测定PAT体积。在纳入时确定冠状动脉危险因素，并进行多变量分析以评估吸烟对PAT的影响，该影响独立于伴随的危险因素。
所有患者的平均PAT体积为215±107 mL。吸烟者的PAT体积显著高于非吸烟者（231±104 mL对201±99 mL，P = 0.03）。与有超过1个危险因素的患者相比，无心血管危险因素的患者PAT体积显著更低（153±155 mL，P<0.05）。吸烟者PAT升高的优势比为2.92 [2.31, 3.61; P<0.001]。
PAT作为动脉粥样硬化活动和炎症负担的个体标志物，在吸烟者中升高。这一发现独立于代谢危险因素，因此可能说明吸烟者与非吸烟者相比炎症活动增加。
