Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Selangor, Malaysia.
Disaster, Outbreak, Crisis and Emergency Management Sector, Surveillance Section, Disease Control Division, Ministry of Health Malaysia, Federal Government Administrative Centre, Putrajaya, Malaysia.
Trop Biomed. 2021 Sep 1;38(3):289-293. doi: 10.47665/tb.38.3.070.
The emergence of a third wave of COVID-19 infection in Malaysia since September 2020 has led to imminent changes in public health prevention and control measures. As high as 96.2% of registered COVID-19 cases and 88.5% of confirmed deaths in Malaysia occurred during this third wave of infection. A phylogenomic study on 258 SARS-CoV-2 full genomes from February 2020-February 2021 has led to the discovery of a novel Malaysian lineage B.1.524. This lineage contains another spike mutation A701V that co-exists with the D614G spike mutation that was predominant in most of the third-wave clusters. The study provides vital genomic insights on the rapid spread of the SARS-CoV-2 variants in Malaysia in conjunction with the presence of a dominant SARS-CoV-2 lineage during the third wave of COVID-19 infection.
自 2020 年 9 月以来，马来西亚出现了第三波 COVID-19 感染，这导致公共卫生预防和控制措施即将发生变化。在第三波感染中，马来西亚有高达 96.2%的注册 COVID-19 病例和 88.5%的确诊死亡病例。对 2020 年 2 月至 2021 年 2 月的 258 个 SARS-CoV-2 全基因组进行的系统基因组学研究发现了一种新型马来西亚 B.1.524 谱系。该谱系包含另一个刺突突变 A701V，与在大多数第三波集群中占主导地位的 D614G 刺突突变共存。该研究提供了有关马来西亚 SARS-CoV-2 变异快速传播的重要基因组见解，同时还存在第三波 COVID-19 感染期间占主导地位的 SARS-CoV-2 谱系。
