Kawa A, Nakamura S, Nakazawa M, Sakaguchi S, Kawabata T, Maeda Y, Kanehisa T
Acta Endocrinol (Copenh). 1977 Dec;86(4):754-7. doi: 10.1530/acta.0.0860754.
Thirty-three Japanese patients with Graves' disease and 106 healthy controls living in the Kagoshima area, the southernmost part of the Japanese mainland, were HLA typed by the NIH method. None of them were related to each other. The only antigen showing an increased frequency in Japanese patients with Graves' disease was HLA-BW35 (corrected P less than 0.02). A decreased frequency of B5 in the patients was also statistically significant (corrected p less than 0.02).
采用美国国立卫生研究院（NIH）的方法，对居住在日本本土最南端鹿儿岛地区的33例格雷夫斯病日本患者和106名健康对照者进行了HLA分型。他们之间均无亲属关系。在日本格雷夫斯病患者中，唯一显示频率增加的抗原是HLA - BW35（校正P值小于0.02）。患者中B5频率降低在统计学上也具有显著意义（校正p值小于0.02）。
