• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

性别对晚期膝关节骨关节炎治疗的影响。

Influence of sex and gender on the management of late-stage knee osteoarthritis.

机构信息

Department of Medical Sciences of Basis, Neurosciences and Organs of Sense, General Hospital, Faculty of Medicine and Surgery, University of Study of Bari, Bari, Italy.

Department of Orthopedic and Trauma Unit, AOU Policlinico Consorziale Hospital, P.zza G. Cesare 11, 70124, Bari, BA, Italy.

出版信息

Musculoskelet Surg. 2022 Dec;106(4):457-467. doi: 10.1007/s12306-021-00725-8. Epub 2021 Aug 7.

DOI:10.1007/s12306-021-00725-8
PMID:34363604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9617829/
Abstract

PURPOSE

The exact nature of sex and gender differences in knee osteoarthritis (OA) among patient candidates for total knee arthroplasty (TKA) remains unclear and requires better elucidation to guide clinical practice. The purpose of this investigation was to survey physician practices and perceptions about the influence of sex and gender on knee OA presentation, care, and outcomes after TKA.

METHODS

The survey questions were elaborated by a multidisciplinary scientific board composed of 1 pain specialist, 4 orthopedic specialists, 2 physiatrists, and 1 expert in gender medicine. The survey included 5 demographic questions and 20 topic questions. Eligible physician respondents were those who treat patients during all phases of care (pain specialists, orthopedic specialists, and physiatrists). All survey responses were anonymized and handled via remote dispersed geographic participation.

RESULTS

Fifty-six physicians (71% male) accepted the invitation to complete the survey. In general, healthcare professionals expressed that women presented worse symptomology, higher pain intensity, and lower pain tolerance and necessitated a different pharmacological approach compared to men. Pain and orthopedic specialists were more likely to indicate sex and gender differences in knee OA than physiatrists. Physicians expressed that the absence of sex and gender-specific instruments and indications is an important limitation on available studies.

CONCLUSIONS

Healthcare professionals perceive multiple sex and gender-related differences in patients with knee OA, especially in the pre- and perioperative phases of TKA. Sex and gender bias sensitivity training for physicians can potentially improve the objectivity of care for knee OA among TKA candidates.

摘要

目的

全膝关节置换术(TKA)患者候选人群中膝关节骨关节炎(OA)的性别差异的确切性质仍不清楚,需要更好地阐明,以指导临床实践。本研究旨在调查医生对性别的影响在膝关节 OA 表现、治疗和 TKA 后结果方面的实践和看法。

方法

由 1 名疼痛专家、4 名骨科专家、2 名物理治疗师和 1 名性别医学专家组成的多学科科学委员会详细制定了调查问题。该调查包括 5 个人口统计学问题和 20 个主题问题。符合条件的医生受访者是那些在所有治疗阶段(疼痛专家、骨科专家和物理治疗师)都治疗患者的医生。所有调查回复均匿名处理,并通过远程分散地理参与进行。

结果

56 名医生(71%为男性)接受了完成调查的邀请。总的来说,医疗保健专业人员表示,与男性相比,女性的症状表现更差、疼痛强度更高、疼痛耐受性更低,需要采取不同的药物治疗方法。疼痛和骨科专家比物理治疗师更有可能指出膝关节 OA 中的性别差异。医生表示,缺乏针对性别差异的特定工具和指征是现有研究的一个重要限制。

结论

医疗保健专业人员认为膝关节 OA 患者存在多种与性别相关的差异,尤其是在 TKA 的术前和围手术期。对医生进行性别偏见敏感培训可以提高 TKA 候选患者膝关节 OA 护理的客观性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2009/9617829/c3d0e1816107/12306_2021_725_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2009/9617829/4677c19b3048/12306_2021_725_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2009/9617829/3b98fdf18fdc/12306_2021_725_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2009/9617829/c3d0e1816107/12306_2021_725_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2009/9617829/4677c19b3048/12306_2021_725_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2009/9617829/3b98fdf18fdc/12306_2021_725_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2009/9617829/c3d0e1816107/12306_2021_725_Fig3_HTML.jpg

相似文献

1
Influence of sex and gender on the management of late-stage knee osteoarthritis.性别对晚期膝关节骨关节炎治疗的影响。
Musculoskelet Surg. 2022 Dec;106(4):457-467. doi: 10.1007/s12306-021-00725-8. Epub 2021 Aug 7.
2
Widespread Pain Is Associated with Increased Risk of No Clinical Improvement After TKA in Women.广泛的疼痛与女性全膝关节置换术后无临床改善的风险增加有关。
Clin Orthop Relat Res. 2020 Jul;478(7):1453. doi: 10.1097/CORR.0000000000001001.
3
Variability in recommendations for total knee arthroplasty among rheumatologists and orthopedic surgeons.风湿科医生和骨科医生对全膝关节置换术的推荐存在差异。
J Rheumatol. 2014 Jan;41(1):47-52. doi: 10.3899/jrheum.130762. Epub 2013 Dec 1.
4
A comparative study of clinical effect of total knee arthroplasty in the treatment of primary osteoarthritis and osteoarthritis of Kashin-Beck disease.全膝关节置换术治疗原发性骨关节炎与大骨节病性骨关节炎的临床疗效对比研究。
Int Orthop. 2020 Sep;44(9):1719-1726. doi: 10.1007/s00264-020-04542-9. Epub 2020 Mar 30.
5
Factors related to the indecision of older adults with knee osteoarthritis about receiving physician-recommended total knee arthroplasty.与患有膝关节骨关节炎的老年人在接受医生推荐的全膝关节置换术时犹豫不决相关的因素。
Disabil Rehabil. 2017 Nov;39(22):2302-2307. doi: 10.1080/09638288.2016.1226407. Epub 2016 Sep 16.
6
Comparison of Expectations and Outcomes in Rheumatoid Arthritis Versus Osteoarthritis Patients Undergoing Total Knee Arthroplasty.类风湿关节炎与骨关节炎患者行全膝关节置换术后的期望与结果比较。
J Arthroplasty. 2019 Sep;34(9):1946-1952.e2. doi: 10.1016/j.arth.2019.04.034. Epub 2019 May 30.
7
Sex differences in negative affect and postoperative pain in patients undergoing total knee arthroplasty.全膝关节置换术后患者的负性情绪和术后疼痛的性别差异。
Biol Sex Differ. 2019 May 6;10(1):23. doi: 10.1186/s13293-019-0237-7.
8
Development and Persistence of Suspected Neuropathic Pain After Total Knee Arthroplasty in Individuals With Osteoarthritis.骨关节炎患者全膝关节置换术后疑似神经性疼痛的发生与持续情况
PM R. 2018 Sep;10(9):903-909. doi: 10.1016/j.pmrj.2018.01.010. Epub 2018 Feb 13.
9
Functional Impairment Is a Risk Factor for Knee Replacement in the Multicenter Osteoarthritis Study.在多中心骨关节炎研究中,功能障碍是膝关节置换的一个风险因素。
Clin Orthop Relat Res. 2015 Aug;473(8):2505-13. doi: 10.1007/s11999-015-4211-3.
10
Gender Disparities in Osteoarthritis-Related Health Care Utilization Before Total Knee Arthroplasty.全膝关节置换术前骨关节炎相关医疗保健利用中的性别差异。
J Arthroplasty. 2016 Oct;31(10):2115-2118.e1. doi: 10.1016/j.arth.2016.03.044. Epub 2016 Apr 7.

引用本文的文献

1
Considerations in modern regenerative medicine for osteoarthritis.现代再生医学治疗骨关节炎的考量因素。
EFORT Open Rev. 2025 Jun 2;10(6):336-344. doi: 10.1530/EOR-2025-0050.
2
Somatosensory and prefrontal cortex activity relates to emotional outcomes and hair cortisol concentration in chronic postsurgical pain.体感皮层和前额叶皮层活动与慢性术后疼痛的情绪结果及毛发皮质醇浓度相关。
Sci Rep. 2025 May 10;15(1):16304. doi: 10.1038/s41598-025-00685-0.
3
Longitudinal association between frailty and pain in three prospective cohorts of older population.

本文引用的文献

1
Sex and gender: modifiers of health, disease, and medicine.性别与健康、疾病和医学。
Lancet. 2020 Aug 22;396(10250):565-582. doi: 10.1016/S0140-6736(20)31561-0.
2
The perspectives of intra-articular therapy in the management of osteoarthritis.关节内治疗在骨关节炎治疗中的观点。
Expert Opin Drug Deliv. 2020 Sep;17(9):1213-1226. doi: 10.1080/17425247.2020.1783234. Epub 2020 Jun 22.
3
Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017.
老年人群三个前瞻性队列中衰弱与疼痛的纵向关联。
J Nutr Health Aging. 2025 Jun;29(6):100537. doi: 10.1016/j.jnha.2025.100537. Epub 2025 Mar 23.
4
Association between grip strength level and fall experience among older Chinese adults: a cross-sectional study from the CHARLS.中国老年人握力水平与跌倒经历之间的关联:来自中国健康与养老追踪调查(CHARLS)的横断面研究
BMC Geriatr. 2025 Mar 6;25(1):156. doi: 10.1186/s12877-025-05735-w.
5
The COVID-19 pandemic caused gender-specific declines in knee surgery rates in Sweden from 2020 to 2021.2020年至2021年期间,新冠疫情导致瑞典膝关节手术率出现了性别差异下降。
J Exp Orthop. 2024 Oct 3;11(4):e70030. doi: 10.1002/jeo2.70030. eCollection 2024 Oct.
6
Investigating and Practicing Orthopedics at the Intersection of Sex and Gender: Understanding the Physiological Basis, Pathology, and Treatment Response of Orthopedic Conditions by Adopting a Gender Lens: A Narrative Overview.在性别交叉领域研究与实践骨科:通过采用性别视角理解骨科疾病的生理基础、病理学及治疗反应:一篇叙述性综述
Biomedicines. 2024 Apr 29;12(5):974. doi: 10.3390/biomedicines12050974.
7
Gender health gap pre- and post-joint arthroplasty: identifying affected patient-reported health domains.关节置换术前和术后的性别健康差距:确定受影响的患者报告的健康领域。
Int J Equity Health. 2024 Feb 27;23(1):44. doi: 10.1186/s12939-024-02131-5.
8
Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success.文化扩增间充质基质细胞治疗:在膝骨关节炎中是否有效?通往临床成功的途径。
Cell Mol Immunol. 2023 Jun;20(6):626-650. doi: 10.1038/s41423-023-01020-1. Epub 2023 Apr 25.
9
Sex and Gender-Related Differences in the Outcome of Total Hip Arthroplasty: A Current Concepts Review.全髋关节置换术后结局的性别差异:当前概念综述。
Medicina (Kaunas). 2022 Nov 22;58(12):1702. doi: 10.3390/medicina58121702.
全球、区域和国家骨关节炎负担 1990-2017 年:2017 年全球疾病负担研究的系统分析。
Ann Rheum Dis. 2020 Jun;79(6):819-828. doi: 10.1136/annrheumdis-2019-216515. Epub 2020 May 12.
4
Higher Disability in Women Than Men Scheduled for Total Knee Arthroplasty for Degenerative Osteoarthritis: A Cross-Sectional Analysis From India.因退行性骨关节炎计划进行全膝关节置换术的女性残疾程度高于男性:来自印度的横断面分析
ACR Open Rheumatol. 2020 Jun;2(6):309-319. doi: 10.1002/acr2.11137. Epub 2020 May 9.
5
Sex and Gender Issues in Pain Management.疼痛管理中的性别与性问题
J Bone Joint Surg Am. 2020 May 20;102 Suppl 1:32-35. doi: 10.2106/JBJS.20.00237.
6
Diagnosis of depression and other patient factors impacts length of stay after total knee arthroplasty.抑郁症诊断及其他患者因素会影响全膝关节置换术后的住院时间。
Arthroplast Today. 2020 Jan 8;6(1):77-80. doi: 10.1016/j.artd.2019.11.010. eCollection 2020 Mar.
7
Gender Differences in Contribution of Smoking, Low Physical Activity, and High BMI to Increased Risk of Early Reoperation After TKA.性别差异在吸烟、低体力活动和高 BMI 对 TKA 后早期再次手术风险增加的贡献。
J Arthroplasty. 2020 Jun;35(6):1545-1557. doi: 10.1016/j.arth.2020.01.056. Epub 2020 Jan 25.
8
Treat-to-target strategy for knee osteoarthritis. International technical expert panel consensus and good clinical practice statements.膝关节骨关节炎的达标治疗策略。国际技术专家小组共识与良好临床实践声明。
Ther Adv Musculoskelet Dis. 2019 Dec 19;11:1759720X19893800. doi: 10.1177/1759720X19893800. eCollection 2019.
9
Multidisciplinary integrated approach for older adults with symptomatic osteoarthritis: SIMFER and SI-GUIDA Joint Position Statement.多学科综合方法治疗有症状的老年骨关节炎:SIMFER 和 SI-GUIDA 联合立场声明。
Eur J Phys Rehabil Med. 2020 Feb;56(1):112-119. doi: 10.23736/S1973-9087.19.05837-4. Epub 2019 Nov 18.
10
Neuroscience and Sex/Gender: Looking Back and Forward.神经科学与性/性别:回顾与展望。
J Neurosci. 2020 Jan 2;40(1):37-43. doi: 10.1523/JNEUROSCI.0750-19.2019. Epub 2019 Sep 5.